SINCE EVOLUTION IS THE BASIS of organismal development (“ontogeny recapitulates phylogeny”), an understanding of evolutionary biology is fundamental to ideas regarding cellular and subcellular organization and function. Although key concepts and findings in cell biology and evolutionary biology might thus be considered complementary to one another, the two disciplines are rarely looked at in th...

Significance Mutations that activate LRRK2 protein kinase cause Parkinson's disease. phosphorylates a subset of Rab GTPases, in particular Rab8 and Rab10. We show here details related to the mechanism by which Rab10 phosphorylation blocks initiation cilia formation, fundamental information how pathogenic interferes with normal cell physiology.

Labor is a physiological event involving a sequential, integrated set of changes within the myometrium, deciduas, and uterine cervix that occur gradually over a period of days to weeks. Biochemical connective tissue changes in the uterine cervix appear to precede uterine contractions and cervical dilation, and all of these events usually occur before rupture of the fetal membranes. In other wor...

is dedicated to innovative approaches to the study of cell and molecular physiology. It is published 12 times AJP-Cell Physiology