BACKGROUND This study aimed to quantify structural and functional changes at the macula during acute exposure to high altitude and to assess their structure/function relationship. This work is related to the Tuebingen High Altitude Ophthalmology (THAO) study. METHODOLOGY/PRINCIPAL FINDINGS Spectral domain optical coherence tomography and microperimetry were used to quantify changes of central...

BACKGROUND Biomarker", a merged word of "biological marker", refers to a broad subcategory of medical signs that objectively indicate the state of health, and well-being of an individual. Biomarkers hold great promise for personalized medicine as information gained from diagnostic or progression markers can be used to tailor treatment to the individual for highly effective intervention in the d...

PURPOSE To evaluate the efficacy of prophylactic ketorolac 0.5% versus nepafenac 0.1% versus placebo on macular volume 1 month after uneventful phacoemulsification and evaluate the health-related quality-of-life (HRQOL) of topical nonsteroidal antiinflammatory drugs (NSAIDs) in the context of cataract surgery. SETTING Hotel Dieu Hospital, Kingston, Ontario, Canada. DESIGN Prospective placeb...

PURPOSE To assess the macular thickness changes after cataract surgery in diabetic patients using optical coherence tomography (OCT). METHODS We retrospectively reviewed the records of 104 diabetic patients who underwent cataract surgery. We examined the changes of macular thickness using OCT before cataract surgery and 1 week, 1-, 2- and 6-months after surgery. The central subfield mean thic...

PURPOSE To report 1-year outcomes of the Prospective Retinal and Optic Nerve Vitrectomy Evaluation study. DESIGN Prospective, controlled, observational study. PARTICIPANTS Eighty eyes of 40 participants undergoing pars plana vitrectomy for epiretinal membrane (ERM), macular hole (MH), or vitreous opacities. METHODS Enrolled participants underwent baseline evaluation of the study (surgical...

This study was design to evaluate the efficacy of cataract surgery with simultaneous intravitreal bevacizumab injection for wet age-related macular degeneration. Of patients who underwent anti-vascular endothelial growth factor injections, performed in 24 eyes (control group), and 27 (bevacizumab group). Best corrected visual acuity, ocular tonometry, anterior chamber inflammation, central subf...

PURPOSE To determine the utility of logarithmic transformation of spectral-domain optical coherence tomography (logSD-OCT) retinal thickness data for assessment of clinically meaningful changes in uveitis-associated macular edema. METHODS Patients with noninfectious uveitis-associated macular edema at our institution between August 2010 and March 2011 were identified. Only those with SD-OCT i...

Results: A total of 2079 children were included in the study, with ages ranging from birth to 17 years. Included were 807 whites, 494 Hispanics, and 474 African Americans, in addition to Asian, unknown race, and mixed-race individuals. African American children had thinner corneas on average than that of both white and Hispanic children (P .001 for both) by approximately 20 μm. Thicker median C...

Background: To employ optical coherence tomography angiography (OCTA) to evaluate the effects of hydroxychloroquine (HCQ) on superficial capillary plexus (SCP) and deep retinal (DCP) in patients affected by rheumatoid arthritis (RA). Methods: Patients with recent diagnosis “definite RA”, based 2010 Rheumatoid Arthritis Classification Criteria, were included a prospective, observational imaging ...