نتایج جستجو برای: centromeric index

تعداد نتایج: 398997  

2014
Charles E. Larsen Dennis R. Alford Michael R. Trautwein Yanoh K. Jalloh Jennifer L. Tarnacki Sushruta K. Kunnenkeri Dolores A. Fici Edmond J. Yunis Zuheir L. Awdeh Chester A. Alper Daniel E. Geraghty

We resequenced and phased 27 kb of DNA within 580 kb of the MHC class II region in 158 population chromosomes, most of which were conserved extended haplotypes (CEHs) of European descent or contained their centromeric fragments. We determined the single nucleotide polymorphism and deletion-insertion polymorphism alleles of the dominant sequences from HLA-DQA2 to DAXX for these CEHs. Nine of 13 ...

Journal: :Cold Spring Harbor symposia on quantitative biology 2006
D Moazed M Bühler S M Buker S U Colmenares E L Gerace S A Gerber E-J E Hong M R Motamedi A Verdel J Villén S P Gygi

Assembly of heterochromatin at centromeric DNA regions in the fission yeast Schizosaccharomyces pombe involves an intimate interplay between chromatin modifying complexes and components of the RNAi pathway. The RNA-induced transcriptional silencing (RITS) complex, containing Chp1, Ago1, Tas3, and centromeric siRNAs, localizes to centromeric DNA repeats and is required for the assembly and maint...

2015
Kiyotaka Nagaki Keisuke Tanaka Naoki Yamaji Hisato Kobayashi Minoru Murata

The kinetochore is a protein complex including kinetochore-specific proteins that plays a role in chromatid segregation during mitosis and meiosis. The complex associates with centromeric DNA sequences that are usually species-specific. In plant species, tandem repeats including satellite DNA sequences and retrotransposons have been reported as centromeric DNA sequences. In this study on sunflo...

2011
Jungseog Kang Jaideep Chaudhary Hui Dong Soonjoung Kim Chad A. Brautigam Hongtao Yu

Human Shugoshin 1 (Sgo1) protects centromeric sister-chromatid cohesion during prophase and prevents premature sister-chromatid separation. Heterochromatin protein 1 (HP1) has been proposed to protect centromeric sister-chromatid cohesion by directly targeting Sgo1 to centromeres in mitosis. Here we show that HP1α is targeted to mitotic centromeres by INCENP, a subunit of the chromosome passeng...

2017
Masatoshi Mutazono Misato Morita Chihiro Tsukahara Madoka Chinen Shiori Nishioka Tatsuhiro Yumikake Kohei Dohke Misuzu Sakamoto Takashi Ideue Jun-Ichi Nakayama Kojiro Ishii Tokio Tani

In fission yeast, the formation of centromeric heterochromatin is induced through the RNA interference (RNAi)-mediated pathway. Some pre-mRNA splicing mutants (prp) exhibit defective formation of centromeric heterochromatin, suggesting that splicing factors play roles in the formation of heterochromatin, or alternatively that the defect is caused by impaired splicing of pre-mRNAs encoding RNAi ...

2017
Meredith B. Metzger Jessica L. Scales Mitchell F. Dunklebarger Allan M. Weissman

Protein degradation by the ubiquitin-proteasome system is essential to many processes. We sought to assess its involvement in the turnover of mitochondrial proteins in Saccharomyces cerevisiae We find that deletion of a specific ubiquitin ligase (E3), Psh1p, increases the abundance of a temperature-sensitive mitochondrial protein, mia40-4pHA, when it is expressed from a centromeric plasmid. Del...

Journal: :Journal of cell science 2003
Tomohiro Hayakawa Tokuko Haraguchi Hiroshi Masumoto Yasushi Hiraoka

Heterochromatin protein 1 (HP1) plays an important role in heterochromatin formation. Three subtypes of HP1, namely HP1alpha, beta, and gamma, have been identified in humans. In this study, using yellow fluorescent protein (YFP) fusion constructs, we examined the intracellular localization of human HP1 subtypes during the cell cycle. During interphase, all three HP1 subtypes were localized to c...

Journal: :Journal of Biology 2004
Gregory P Copenhaver

Centromere function is remarkably conserved between species, yet the satellite sequences that make up centromeric DNA are highly divergent. Proteins that bind these sequences appear to be evolving under positive selection, supporting a model wherein the interplay between centromeric repeats and the proteins that bind them creates an opportunity for an intriguing phenomenon known as centromere-b...

2014
Ana Paço Filomena Adega Nevenka Meštrović Miroslav Plohl Raquel Chaves

With the goal to contribute for the understanding of satellite DNA evolution and its genomic involvement, in this work it was isolated and characterized the first satellite DNA (PSUcentSat) from Phodopus sungorus (Cricetidae). Physical mapping of this sequence in P. sungorus showed large PSUcentSat arrays located at the heterochromatic (peri)centromeric region of five autosomal pairs and Y-chro...

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