Cephalosporins, particularly cefepime, exert neurotoxic side effects that can lead to status epilepticus. These neurotoxic side effects include myoclonus, dystonic movements, tremor, asterixis, seizure, status epilepticus, encephalopathy, and sometimes coma. Status epilepticus, particularly nonconvulsive status epilepticus (NCSE), is a well-known but unusual complication in patients with altere...

The present study aims at comparing the in-vitro susceptibility of six commercially available cephalosporin--BLI combinations with cephalosporins alone against hospital isolates of Gram negative bacilli. Gram negative bacilli, numbering 500, isolated from various clinical samples, were included in the study. The isolates were also screened for ESBL production by the methods recommended by CLSI....

A study of the susceptibility to cefotaxime and six other cephalosporins in 213 nonselected strains of nine different bacterial species clearly showed that cefotaxime was the most active against aerobic gram-negative bacilli. The same pattern emerged with 84 cephalothin-resistant strains of five enterobacterial species, but the mean minimal inhibitory concentration values for all cephalosporins...

Twelve years ago an annotation was published in Archives of Disease in Childhood regarding the antibiotic treatment of suspected neonatal meningitis. The authors recommended the use of cephalosporins rather than chloramphenicol and advocated intraventricular aminoglycoside treatment in selected cases. They noted the absence of clinical trials with third generation cephalosporins that showed an ...

The spread of Neisseria gonorrhoeae strains with reduced susceptibility to extended-spectrum cephalosporins is an increasing public health threat. Using Etest and multiantigen sequence typing, we detected sequence type 1407, which is associated with reduced susceptibilities to extended-spectrum cephalosporins, in 4 major populated regions in California, USA, in 2012.

-lactamases are a major cause of resistance to the -lactam antibiotics. Many classes of -lactamases have been described depending on substrate specificity and susceptibility to inhibitors [1]. Amp C -lactamases are able to hydrolyse all penicillins and cephalosporins and are not inhibited by clavulanic acid. Bacteria that produce these enzymes are resistant to all penicillins including lac...

A series of C-3' ortho dihydroxyphthalimido cephalosporins 3-7 has been prepared by reaction of C-3' aminomethyl cephalosporin 41 with the corresponding N-carboethoxyphthalimides 23-25, 37, 38. These new cephalosporins exhibit excellent in vitro Gram-negative activities, including Pseudomonas aeruginosa, excellent beta-lactamases stability and pharmacokinetics equivalent or better than ceftriax...

therapy in resistant enteric fever, various drugs singly, or in combination, such as cotrimoxazole and cephalosporins, or cephalexin and gentamicin, third generation cephalosporins and newer quinolones have been tried with varying results. This communication describes our observations on the clinical profile of children with enteric fever due to MDRST infection and, compare different drug regim...