Barbiturate Protection From Cerebral Infarction in Primates • Baboons were anesthetized with halothane or pentobarbital prior to middle cerebral artery (MCA) occlusion to test the protective effect of barbiturates against stroke in primates. Significantly less infarction was found in animals that received 90 mg per kilogram pentobarbital or more than occurred in control animals. Because of card...

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! Barbiturate Protection in Acute Focal Cerebral Ischemia • We have found that anesthetic technique modifies the neurological and pathological se-quelae of unilateral middle cerebral artery and internal carotid artery occlusion in dogs. Occlu-sion was performed in seven groups of six dogs during each of the following anesthetic regimens: light (0.8%) halothane, "awake," deep (1.9%) halothane, d...

Background: Leukemia inhibitory factor (LIF) is a neurortophic cytokine which plays an important role in the neural cell survival. Expression of LIF and its receptor, LIFR, in different brain regions has been demonstrated. Based on evidences LIF plays an important role in the modulation of neurogenesis and glial responses to injury. Up-regulation of LIF after central nervous system (CNS) damage...

Abstract Cerebral ischemia is an extremely complex disease that can be caused by a variety of factors. cause great harm to human body. Sevoflurane volatile anesthetic frequently used in clinic, and has lot advantages, such as quick induction general anesthesia, anesthesia recovery, no respiratory tract irritation, muscle relaxation, small cycle effect. The mechanism sevoflurane preconditioning ...

Complete circulatory arrest, deep hypothermia, and barbiturate cerebral protection are efficacious adjuncts in the surgical treatment of selected giant intracranial aneurysms. These techniques were utilized in seven patients, one with a large and six with giant basilar artery aneurysms; four had excellent results, one had a good result, one had a fair outcome, and one died. The rationale for th...