Chaelochalasin A (1). a new bioactive fungal metabolite with a previously undescribed ring system. has been isolated from an EIOAc extract of Chaetomium brasiliense (NRRL 22999). The structure of I was determined by NMR experiments and single-crystal X-ray diffraction analysis. © 1998 ElseVier SCience Ltd. All nghts reserved.

Onychomycosis is usually caused by dermatophytes, but some nondermatophytic molds and yeasts are also associated with invasion of nails. The genus Chaetomium is a dematiaceous nondermatophytic mold found in soil and plant debris as a saprophytic fungus. We report the first Korean case of onychomycosis caused by Chaetomium globosum in a 35-year-old male. The patient showed brownish-yellow discol...

Two new indole alkaloids chaetocochin J (1) and chaetoglobinol A (8), along with chetomin (2), chetoseminudin A (3), cochliodinol (9), and semicochliodinol (10), were isolated from the rice culture of the fungus Chaetomium globosum. Their structures were elucidated by spectral analysis. Three new epipolythiodioxopiperazines, chaetocochins G-I (5-7), were identified by the combination of UPLC an...

The antimicrobial efficacy of methanol, ethyl acetate, chloroform and butanol extracts of fungus Chaetomium cupreum was determined by employing well diffusion and broth micro-dilution techniques. Chaetomium species are the largest genus of saprophytic ascomycetous fungus, which belongs to the class Sordariomyetes and family Chaetomiaceae. Ethyl acetate and butanol extracts exhibited antibacteri...

The Indian Academy of Neurosciences (IAN) has completed 25 years of its establishment and celebrated 2007 as its silver jubilee year. The academic activities of this celebration started last year with the successful organization of the 24th Conference of the IAN at Lucknow. As part of the silver jubilee celebration, four symposia were organized throughout 2007 at Chicago (USA), Lucknow, Gwalior...

The coronary haemodynamic effects of nifedipine and glyceryl trinitrate were compared in 22 patients undergoing investigations for suspected coronary artery disease. Myocardial blood flow was estimated by the coronary sinus thermodilution technique. In sinus rhythm nifedipine increased mean coronary sinus flow from 135 ml/min to 152 m/min, and reduced arterio-coronary sinus oxygen difference fr...

The antifungal effect and mucolytic activity of a newly screened biocontrol strain Chaetomium subaffine LB-1 were researched in this study. results found that has good effects on the test plant pathogenic fungi Botrytis cinerea Pers. ex Fr., Fusarium oxysporum f. sp. cucumerinum Owen Alternaria solani (Ellis & Martin) Sorauer dual culture assay, with inhibition rates 61.39, 50.34 51.22%, respec...