zinc is a substance that regulates neural excitability by binding whit sodium channel and potassium channel. the efficiency of free zinc ion, make down the neural survival rate, reduced the peak amplitude of na+ and make depolarization na channel, increased the peak amplitude of transition outward k+ currents and delayed rectifier. also it is an effective blocker of one subtype of tetrodoxine (...

*Correspondence: [email protected] 1School of Economics and Management, Tongji University, Siping Road, Shanghai 200092, China Full list of author information is available at the end of the article Abstract This paper explores a supply chain pricing competition problem in a two-echelon supply chain with one manufacturer and two competing retailers. The manufacturing costs, sales costs, and ma...

In this paper, I analyze documentary evidence from a pharmaceutical company's strategic marketing campaign to expand the sale of an antipsychotic medication beyond its conventional market. I focus on the role of the managerial function known as channel marketing, the task of which is to minimize friction, achieve coordination and add value in the distribution of the company's products. However,...

Supply quality management is becoming an important part of a manufacturer‟s work with suppliers, and has recently received significant attention from researchers. This paper focuses on a supply chain system that consists of a supplier and two competing manufacturers, examines quality strategies in different cooperative mechanisms and investigates the effects of different cooperative mechanisms ...

Mechanosensitive (MS) channels that provide protection against hypoosmotic shock are found in the membranes of organisms from the three domains of life: bacteria, archaea, and eucarya. Two families of ubiquitous MS channels are recognized, and these have been designated the MscL and MscS families. A high-resolution X-ray crystallographic structure is available for a member of the MscL family, a...

Multicasting can be an effective routing service in wireless mesh networks (WMNs), which have gained significant acceptance in recent years due to its potentials of providing a low-cost wireless backhaul service to mobile clients. Many applications in WMNs require efficient and reliable multicast communication, i.e., with high delivery ratio but with less overhead among a group of recipients. H...

The recently discovered epithelial sodium channel (ENaC)/degenerin (DEG) gene family encodes sodium channels involved in various cell functions in metazoans. Subfamilies found in invertebrates or mammals are functionally distinct. The degenerins in Caenorhabditis elegans participate in mechanotransduction in neuronal cells, FaNaC in snails is a ligand-gated channel activated by neuropeptides, a...

introduction: we have recently reported the presence of two potassium currents with 598 and 368 ps conductance in the rough endoplasmic reticulum (rer) membrane. the 598 ps channel was voltage dependent and atp sensitive. however, the 368 ps channel was rarely observed and its identity remained obscure. since cationic channels in intracellular organelles such as mitochondria and rer play import...