نتایج جستجو برای: childhood acute myeloid leukemia
تعداد نتایج: 833756 فیلتر نتایج به سال:
Chronic myeloid leukemia is a ph-positive myeloproliferative disease, which usually manifested by hyperleukocytosis and massive splenomegaly. rare in childhood adolescence, it accounts for 2 to 3 % of all leukemias cases. priapism manifestation chronic an urgent urological condition that requires timely treatment prevent long-term complications, particular, erectile dysfunction.This review pres...
background: the wilms tumor 1 (wt1) gene is originally defined as a tumor suppressor gene and a transcription factor that overexpressed in leukemic cells. it is highly expressed in more than 80% of acute myeloid leukemia (aml) patients, both in bone marrow (bm) and in peripheral blood (pb), and it is used as a powerful and independent marker of minimal residual disease (mrd);we have determined ...
OBJECTIVE This study investigated the co-existence of Leishmania chagasi infection and childhood leukemia in patients naïve to treatment; this has serious clinical and epidemiological implications. METHODS The seroprevalence of L. chagasi antibodies prior to any treatment was investigated in children with clinical features of acute leukemia. Serological tests were performed in 470 samples dra...
Acute leukemia is reported to be less common in developing countries compared to non-Hodgkins lymphomas which is the most common childhood malignancy. A retrospective analysis was performed to identify the clinicopathological features of acute leukemias of childhood at the Oncology Department of Allama Iqbal Medical College, Lahore. The commonest malignancy in the under 15 years age group was l...
To characterize the incidence, clinical features and genetics of ETV6-ABL1 leukemias, representing targetable kinase-activating lesions, we analyzed 44 new and published cases of ETV6-ABL1-positive hematologic malignancies [22 cases of acute lymphoblastic leukemia (13 children, 9 adults) and 22 myeloid malignancies (18 myeloproliferative neoplasms, 4 acute myeloid leukemias)]. The presence of t...
BACKGROUND The hypocellular variant of acute myeloid leukemia accounts for less than 10% of all cases of adult acute myeloid leukemia. It is defined by having less than 20 percent of cellular bone marrow in a biopsy at presentation. It is unclear in the literature whether the outcome of hypocellular acute myeloid leukemia differs from that of non-hypocellular acute myeloid leukemia. DESIGN AN...
acute lymphoblastic leukemia (all) is the most common form of childhood cancer representing 80-85% of all leukemia. we describe a 3 years old girl with pain, swelling and tenderness in extremities since 8 months prior to her present admission. x-ray of extremities revealed callus formation, osteopenia and site of healed fractures. bone marrow aspiration revealed all-l2 with normal peripheral sm...
Background: Leukemia is one of the major causes of mortality and disability and the seventh most prevalent cancer worldwide. It has various effects on different aspects of physical, psychological, reproductive, social, and economic performance of human life. This study compared the quality of life of patients with different types of leukemia hospitalized in Ayatollah Khansari Hospital in Arak- ...
Acute myeloid leukemia carrying NPM1 mutations and cytoplasmic nucleophosmin (NPMc(+) acute myeloid leukemia) represents one-third of adult AML (50-60% of all acute myeloid leukemia with normal karyotype) and shows distinct biological, pathological and clinical features. We confirm in 2562 patients with acute myeloid leukemia our previous observation that NPM1 mutations and cytoplasmic nucleoph...
Activating mutations in protein tyrosine phosphatase 11 (Ptpn11) have been identified in childhood acute leukemias, in addition to juvenile myelomonocytic leukemia (JMML), which is a myeloproliferative disorder (MPD). It is not clear whether activating mutations of this phosphatase play a causal role in the pathogenesis of acute leukemias. If so, the cell origin of leukemia-initiating stem cell...
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