The overall prognosis for most pediatric cancers is good. Mortality for all childhood cancers combined is approximately half what it was in 1975, and the survival rates of many malignancies continue to improve. However, the incidence of childhood cancer is significant and the related emergencies that develop acutely carry significant morbidity and mortality. Emergency providers who can identify...

Parental exposure to pesticides may contribute to childhood cancer risk. Through the Agricultural Health Study, a prospective study of pesticide applicators in Iowa and North Carolina, we examined childhood cancer risk and associations with parental pesticide application. Identifying information for 17,357 children of Iowa pesticide applicators was provided by parents via questionnaires (1993-1...

AIMS To study the risk of childhood cancer in relation to parental occupation and related exposures. METHODS Self reported occupational data from mothers and fathers of 3838 children with cancer and 7629 control children were analysed. Odds ratios were calculated for 31 "occupational groups" by parent, diagnostic group (leukaemia, acute lymphoblastic leukaemia (ALL), central nervous system tu...

OBJECTIVES To describe the patterns of childhood cancers in Hadhramout Sector, Yemen between January 2002 and December 2014.  METHODS This descriptive retrospective study was based on secondary data from Hadhramout Cancer Registry, Hadhramout, Yemen. All Yemeni children under age of 15 years, who were diagnosed with  cancer were included. The International Childhood Cancer Classification syst...

Angiogenesis is a target shared by both adult epithelial cancers and the mesenchymal or embryonal tumors of childhood. Development of antiangiogenic agents for the pediatric population has been complicated by largely theoretical concern for toxicities specific to the growing child and prioritization among the many antiangiogenic agents being developed for adults. This review summarizes the mech...

We analyzed population-based childhood cancer incidence rates throughout California in relation to agricultural pesticide use. During 1988-1994, a total of 7,143 cases of invasive cancer were diagnosed among children under 15 years of age in California. Building on the availability of high-quality population-based cancer incidence information from the California Cancer Registry, population data...

OBJECTIVE Epidemiologic evidence indicates that prenatal vitamin supplementation reduces risk for some childhood cancers; however, a systematic evaluation of population-based childhood cancer incidence trends after fortification of enriched grain products with folic acid in the United States in 1996-1998 has not been previously reported. Here we describe temporal trends in childhood cancer inci...

Of all cancers in childhood (by WHO definition: O-14 year age group), leukemias constitute one of the most important groups of tumors. Our understanding of the biologic features of the childhood leukemias has increased greatly over the past decade. The ability to discern cytogenetic and molecular differences among morphologically and immunologically similar populations of leukemic cells has hel...

BACKGROUND Very little is known about the regional variation in the incidence of childhood malignancies in Africa. The aim of the study was to perform a comprehensive analysis of the distribution of childhood cancer in Sub-Saharan Africa and compare the results to the Globocan estimations. METHODS A letter of invitation to participate was sent to all registry centers in Africa registered with...

A young child being diagnosed with cancer naturally generates a pretty melancholy reaction. Each cancer can be managed with a vast array of treatment options that are available either individually or as a combination, the final goal of which is total eradication of the condition in the affected individual. Since, most of these treatments are administered during the age of tooth formation, they ...