The International League Against Epilepsy (ILAE) Subcommittee for Pediatric Neuroimaging examined the usefulness of, and indications for, neuroimaging in the evaluation of children with newly diagnosed epilepsy. The retrospective and prospective published series with n > or = 30 utilizing computed tomography (CT) and magnetic resonance imaging (MRI) (1.5 T) that evaluated children with new-onse...

A total of 201 adults with Down syndrome were investigated, of whom 32 (15.9%) had epilepsy. A bimodal age distribution for seizure onset in childhood and later in middle-age was found. Good seizure control was associated with early onset epilepsy. Down syndrome adults with epilepsy scored significantly higher overall on the adaptive behaviour profile but did not have significantly greater mala...

Background Epilepsy is among the most common neurological disorders in childhood, prevalence of which is increasing. Unpredictable and chronic nature of the disease affects physical, social and mental functions of the children and their family. This study was aimed to compare behavioral problems in epileptic children group versus healthy control group. Materials and Methods This study is a cas...

PURPOSE MicroRNA (miRNA), functions as gene regulators, plays crucial roles in pathogenesis of epilepsy. We hypothesized that single nucleotide polymorphisms (SNPs) in miRNA may be associated with childhood epilepsy. METHOD We first genotyped the selected four SNPs (miR-146a rs57095329, miR-149 rs2292832, miR-196a2 rs11614913, and miR-499 rs3746444) in 267 paired childhood epilepsy patients a...

OBJECTIVE To determine the prognosis of seizures in epileptic children and identify early predictors of intractable childhood epilepsy. STUDY DESIGN Case-control study. PLACE AND DURATION OF STUDY The Epilepsy Centre of the Children's Hospital Lahore, from February 2005 to April 2007. PATIENTS AND METHODS All children (aged 1 month to 16 years) with idiopathic or cryptogenic epilepsy who ...

Carbamazepine oral suspension (100mg/5ml), 100mg and 200mg chewable tablets are proposed for addition to the Model List of Essential Medicines, for use in the management of epilepsy in children. It is at least as effective as phenobarbitone, phenytoin and sodium valproate in the management of partial and tonic-clonic seizures in children. Carbamazepine is available in the UK as a sugar free ora...