An important property of electromagnetic fields, which arises from the interaction between fields and chiral molecules, is called optical chirality. By enhancing this field property, while maintaining constant input power, we are able to increase absorption of circularly polarized light by chiral molecules of a certain handedness. This enhancement is achieved through the use of achiral plasmoni...

The electrochemical response of S- and R-naproxen enantiomers was investigated on L-cysteine/reduced graphene oxide modified glassy carbon electrode (L-Cys/RGO/GCE). The production of the reduced graphene oxide and L-cysteine on the surface of the glassy carbon electrode was done by using electrochemical processes. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were us...

One of the problems encountered in CE separations of basic compounds is the adsorption of analytes onto the negatively charged capillary wall which could lead to poor repeatability of migration time and peak area. Additionally, separation of enantiomers of chiral of basic drugs is commonly carried out in low pH buffer which contributes to strong ionic interaction of the cationic drug ions with ...

The development of chiral stationary phases (CSPs) for liquid chromatography (LC) revolutionized the enantioseparation and, nowadays, different types of CSPs are commercially available. Polysaccharide-based CSPs are one of the most versatile and widely used for both analytical and preparative applications and they are able to resolve several classes of racemates. Phenylcarbamates of amylose and...

The ways of binding optically active ligands, mainly of the amino acid type, to cross—linked polymers of styrene, acrylamide or glycidylmethacrylate are reviewed. When coordina— ted to transition metal ions, these polymers display a high discriminating ability in sorption of optical isomers of corn— pounds capable of forming mixed—ligand complexes. The kinetic performance of the ligand—exchangi...

456 biggest problems is in understanding the fundamental mechanisms involved and predicting the CSP to be used for specific problems. Although Pirkle phases and cyclodextrin phases offer the best rationale for use, in general most decisions are based on empirical experiments, with a degree of justification post fact0 in terms of the proposed mechanism involved. The protein columns based on AGP ...

A reliable method is presented for the chiral separation of three basic drugs (mexiletine, chlorpheniramine and propranolol) with serum albumins (human and porcine, HSA and PSA) as chiral selectors by capillary electrophoresis in combination with the partial filling technique. Based on the systematic optimization of operation variables, the chiral separation of mexiletine, chlorpheniramine and ...

I describe a mechanism to understand the relation between chiral-symmetry breaking and eigenmodes of the Dirac operator in lattice QCD with Kogut-Susskind sea quarks. It can be shown that if chiral symmetry is spontaneously broken, the eigenvalues λi should behave as z(i)/V for large volume V , where z(i) is the i-th zero of the Bessel function. With neither chiral nor λ extrapolation, one can ...

A chiral N,N'-dioxide-Ni(II) complex was found to exhibit highly enantioselective fluorescent recognition of chiral amines and amino alcohols. It can be used to determine their concentration and ee value. Using a 96-well plate, high-throughput screening for enantiomer discrimination was accomplished.