Some new mono-and bis-polycyclic aromatic spiro-beta-lactams and bis-non spiro-polycyclic aromatic beta-lactams have been synthesized from imines derived from anthracene-9-carbaldehyde, 2-naphtaldehyde and a ketene derived from 9H-xanthene-9-carboxylic acid and phenoxyacetic acid by a [2+2] cycloaddition reaction. The cycloadducts were characterized by spectral data, including 1H-NMR, 13C-NMR, ...

A hexafullereno-diporphyrinoid was obtained in a sequence of cycloaddition steps using porphyrins programmed for [4+2]-cycloaddition reactions and C(60)-fullerene.

sulfonic acid functionalized sba-15 (sba-pr-so3h) with pore size 6 nm as an efficient heterogeneous nanoporous solid acid catalyst exhibited good catalytic activity in the biginelli-like reaction in the synthesis of spiroheterobicyclic rings with good yield and good recyclability. spiro-pyrimidinethiones/spiro-pyrimidinones-barbituric acid derivatives were synthesized in a simple and efficient ...

Synthesis of (4',5'-diaza-9'-fluorene)-spiro-5-hydantoin: The paper presents a method for synthesis of (4',5'-diaza-9'-fluorene)-spiro-5-hydantoin. The newly obtained compound was synthesized by a treatment of 4,5-diazafluoren-9-one with sodium cyanide, ammonium carbonate, ethanol and ammonium hydroxide at high pressure and high temperature. The structure of (4',5'-diaza-9'-fluorene)-spiro-5-hy...

carbon nanotubes (cnts) are specific structures with valuable characteristics. in general, the structure of each nanotube is defined by a unique chiral vector. in this paper, different structures of short single-walled cnts are simulated and their mechanical properties are determined using finite element method. for this aim, a simple algorithm is presented which is able to model the geometry o...

6'-(4-Chlorophenyl)-spiro[cyclohexane-1,2'-thieno[3,2-d][1,3] oxazin]-4'(1'H)-one (1) was synthesized and used as a starting material for the synthesis of a novel series of spiro compounds having biologically active sulfonamide 2a-e and 3'-(4-acetylphenyl)-6'- (4-chlorophenyl)-1'H-spiro[cyclohexane-1,2'-thieno[3,2-d] pyrimidine-4'(3'H)-one (3). Compound 2a was used as a key intermediate for the...

A facile construction of the spiro[indole-3,2'-pyrrolidine] skeleton, through diacetoxyiodobenzene (PIDA) mediated C-N bond-forming dearomatization of C3 sulfonamide linked indole derivatives, has been developed. A variety of spiro-indolepyrrolidines were obtained in moderate to excellent yields under mild conditions.

An exploration of the chemistry of the spiro-mamakone system, exemplified by the cytotoxic, fungal metabolite spiro-mamakone A, is presented. The first reported synthesis of the spiro-mamakone carbon skeleton was achieved, as well as the synthesis of a variety of closely related analogues of the natural product. Biological testing of the synthetic analogues generated a structure-activity profil...

The crystal structures of the new compounds spiro[cyclohexane-1,3’-indol]-2’(1’H)-one (1), (rel-1R,2S)-spiro[bicyclo[2.2.1] heptane-2,3’-indol]-2’(1’H)-one (2) and spiro[indole-3,2’-tricyclo[3.3.1.1]decan]-2(1H)-one (3) have been determined by low temperature single crystal X-ray diffraction. The effects of substitution on the hydrogen bonding pattern is compared between all three compounds.

One of the problems encountered in CE separations of basic compounds is the adsorption of analytes onto the negatively charged capillary wall which could lead to poor repeatability of migration time and peak area. Additionally, separation of enantiomers of chiral of basic drugs is commonly carried out in low pH buffer which contributes to strong ionic interaction of the cationic drug ions with ...