To examine the effects of aberrant expression of class II major histocompatibility complex (MHC) proteins on tolerance development, transgenic mice expressing the I-Ad genes under control of the pancreatic elastase promoter were produced. Such transgenic mice express I-Ad exclusively on exocrine pancreas, without expression in thymus or by lymphocytes. No spontaneous development of autoimmune r...

BACKGROUND The measurement of biomarkers in cerebrospinal fluid (CSF) has gained increasing acceptance in establishing the diagnosis of some neurodegenerative diseases. Heart-type fatty acid-binding protein (H-FABP) was recently discovered in CSF and serum of patients with neurodegenerative diseases. OBJECTIVE We investigated H-FABP in CSF and serum alone and in combination with CSF tau prote...

BACKGROUND As an efficient disposal method of food waste, anaerobic digestion (AD) for biogas production is widely used. In order to understand the enhanced efficiency and stability of AD by appropriate amounts of ammonia and volatile fatty acids (NH4 (+)/VFAs), the characteristics of the corresponding microbial community with ammonium acetate supplement were investigated by denatured gradient ...

Proton magnetic resonance spectroscopy ((1)H-MRS) is sensitive to early neurodegenerative processes associated with Alzheimer's disease (AD). Although (1)H-MRS metabolite ratios of N-acetyl aspartate (NAA)/creatine (Cr), NAA/myoinositol (mI), and mI/Cr measured in the posterior cingulate gyrus reveal evidence of disease progression in AD, pathologic underpinnings of the (1)H-MRS metabolite chan...

Let V be a standard subspace in the complex Hilbert space H and U : G \to U(H) unitary representation of finite dimensional Lie group. We assume existence an element h algebra such that U(exp th) is modular group involution J_V normalizes U(G). want to determine semigroup $S_V = \{ g\in U(g)V \subseteq V\}.$ In previous work we have seen its infinitesimal generators span on which ad defines 3-g...

We provide an explicit bijection between the ad-nilpotent ideals of a Borel subalgebra of a simple Lie algebra g and the orbits of Q̌/(h + 1)Q̌ under the Weyl group (Q̌ being the coroot lattice and h the Coxeter number of g). From this result we deduce in a uniform way a counting formula for the ad-nilpotent ideals.

Many cell types form three-dimensional aggregates (MCS; multicellular spheroids), when they are cultured under microgravity. MCS often resemble the organ, from which the cells have been derived. In this study we investigated human MCF-7 breast cancer cells after a 2 h-, 4 h-, 16 h-, 24 h- and 5d-exposure to a Random Positioning Machine (RPM) simulating microgravity. At 24 h few small compact MC...

An efficient methodology for the preparation of the α-tetrasubstituted proline analog (S,S,S)-2-methyloctahydroindole-2-carboxylic acid, (S,S,S)-(αMe)Oic, and its enantiomer, (R,R,R)-(αMe)Oic, has been developed. Starting from easily available substrates and through simple transformations, a racemic precursor has been synthesized in excellent yield and further subjected to HPLC resolution using...