The objective of this study was to prepare a suitable formulation for dermal delivery of diflucortolone valerate (DFV) that would maintain the localization in skin layers without any penetration and to optimize efficiency of DFV. Drug-loaded lecithin/chitosan nanoparticles with high entrapment efficiency (86.8%), were successfully prepared by ionic interaction technique. Sustained release of DF...

Nanochitosan is a nanoparticle of chitosan with size between 100-400 nm. has higher antibacterial ability than ordinary chitosan. The manufacture into nanochitosan can be done by ionic gelation method, namely the complexation polyelectrolyte positively charged and negatively sodium tripolyphosphate. morphology in form whole sphere typical functional groups such as amine, hydroxyl carboxyl group...

Memantine hydrochloride is a reversible cholinesterase inhibitor used in the treatment of Alzheimer’s disease, low-moderate affinity, uncompetitive n-methyl-d-aspartate (NMDA) receptor antagonist, with strong voltage dependency and rapid blocking/unblocking kineticsThe present study was explore potential mamentine loaded nanoparticle.with varying quantity chitosan byionotropic gelation method.T...

Statement of Purpose: Various nanoparticle systems with a long blood circulation time and a high tumor accumulation have been reported for cancer diagnosis and treatment based on their EPR (enhanced permeability and retention) effect [1,2]. Here, we prepared several Pluronic-based nano-carriers attached with an NIR dye, and characterized their cellular uptake and in-vivo tumor targeting efficie...

BACKGROUND AND METHODS A new cyclosporin A-loaded, PEGylated chitosan-modified lipid-based nanoparticle was developed to improve upon the formulation of cyclosporin A. PEGylated chitosan, synthesized in three steps using mild reaction conditions, was used to modify the nanoparticles. Cyclosporin A-loaded, PEGylated chitosan-modified nanoparticles were prepared using an emulsification/solvent ev...

Recently, cell-penetrating peptides have been proposed to translocate antibodies, proteins, and other molecules in targeted drug delivery. The proposed study presents the synthesis and characterization of a peptide-based chitosan nanoparticle for small interfering RNA (siRNA) delivery, in-vitro. Specifically, the synthesis included polyethylene glycol (PEG), a hydrophilic polymer, and trans-act...

objective(s): the purpose of this study is about the preparation and evaluation of nanoparticles composed of thiolated methylated pyridinyl chitosan (tmpc) which are made p.e.c method, for bucal drug delivery of insulin.materials and methods: first of all have to synthesize methylated pyridinyl chitosan and then for (tmpc) l-cysteine should be attached to methylated pyridinyl chitosan by the fo...

We designed a study for photodynamic therapy (PDT) using chitosan coated Mg-Al layered double hydroxide (LDH) nanoparticles as the delivery system. A Food and Drug Administration (FDA) approved near-infrared (NIR) fluorescent dye, indocyanine green (ICG) with photoactive properties was intercalated into amine modified LDH interlayers by ion-exchange. The efficient positively charged polymer (ch...