OBJECTIVES Chloramphenicol is an old broad-spectrum antibiotic. We assessed its efficacy and safety. METHODS This was a systematic review and meta-analysis. Electronic databases were searched to identify randomized controlled trials (RCTs) that assessed patients, of any age, with systemic bacterial infections that can cause sepsis and compared chloramphenicol alone versus other antibiotics. N...

BACKGROUND The environmental gliding bacteria Lysobacter are emerging as a new group of biocontrol agents due to their prolific production of lytic enzymes and potent antibiotic natural products. These bacteria are intrinsically resistant to many antibiotics, but the mechanisms behind the antibiotic resistance have not been investigated. RESULTS Previously, we have used chloramphenicol acetyl...

By LEIF G. SUHRLAND AND AUSTIN S. WEISBERGER T HE UNCOMMON OCCURRENCE of aplastic anemia following the therapeutic administration of chloramphenicol is well documented.’ However, erythropoietic depression associated with changes in iron metabolism, reticulocytopenia and vacuolization of erythroblasts is more frequent.2’3 If chloramphenicol is continued after these changes appear, leukopenia and...

Chloramphenicol is a broad-spectrum antibiotic used for the treatment of many infectious diseases and has become one of the major seafood contaminants. Hematologic disorders such as aplastic anemia and leukemia induced by chloramphenicol are a major concern. However, the mechanism underlying chloramphenicol-induced leukemogenesis is not known. By investigating the effects of chloramphenicol on ...