OBJECTIVES/HYPOTHESIS Although the migration of its squamous outer surface of the tympanic membrane has been well characterized, there is a paucity of data available concerning the migratory behavior of its medial mucosal surface. Existing theories of primary acquired cholesteatoma pathogenesis do not adequately explain the observed characteristics of the disease. We propose a new hypothesis, b...

UNLABELLED Middle ear cholesteatoma is an important and relatively common disorder which may have serious consequences. AIM The purpose was to conduct a retrospective study of the statistics of 1,146 middle ear surgical procedures for middle ear cholesteatoma in adults and children of low income living in distant areas from our city. METHODS From 1962 to 1988 there were 1,146 surgeries for ...

In this article we describe the surgical management of petrous bone cholesteatoma, a rare form of an epidermoid cyst growing medially into the petrous part of the temporal bone. In our series of 5 patients, high resolution Computerized Tomography (CT) played an essential role in the diagnosis of this pathological entity. CT was also important in planning for the surgical access to this intricat...

Cholesteatoma is a destructive and expanding growth of keratinizing squamous epithelium in the middle ear or petrous apex. The molecular and cellular processes of the pathogenesis of acquired middle ear cholesteatoma have not been fully understood. In this study, comparative proteomic analysis was conducted to investigate the roles of specific proteins in the pathways regarding keratinocyte pro...

OBJECTIVES/HYPOTHESIS To introduce a simple and alternative surgical technique, minimally invasive transcanal myringotomy (MITM), for early stage congenital cholesteatoma in children and to evaluate the feasibility and results of MITM for management of early stage congenital cholesteatoma with respect to its effectiveness and safety. STUDY DESIGN Retrospective review. METHODS Between August...

BACKGROUND Congenital cholesteatoma may be expected in abnormally developed ear, it may cause bony erosion of the middle ear cleft and extend to the infratemporal fossa. We present the first case of congenital cholesteatoma of the infratemporal fossa in a patient with congenital aural atresia that has been complicated with acute mastoiditis. CASE PRESENTATION A sixteen year old Egyptian male ...

OBJECTIVE To investigate the diagnostic value of non-echo planar diffusion-weighted magnetic resonance imaging (DW-MRI) for primary and recurrent/residual (postoperative) cholesteatoma in adults (≥18 years) after canal wall up surgery. DATA SOURCES We conducted a systematic search in PubMed, Embase, and Cochrane up to October 22, 2014. REVIEW METHODS All studies investigating non-echo plana...

INTRODUCTION AND OBJECTIVES The diagnosis of cholesteatoma is based on clinical evaluation and computed tomography. New non-echo-planar diffusion-weighted magnetic resonance imaging (MRI) techniques, without intravenous contrast, are capable of differentiating cholesteatoma from inflammatory tissue, cholesterol granuloma and granulation tissues. The technique is very helpful in differential dia...

INTRODUCTION In developing countries, chronic otitis media (COM) and cholesteatoma are relatively prevalent. Within the field of otology, COM surgery remains one of the most common surgical treatments. Most recent studies evaluating the potential prognostic factors in COM surgery have addressed graft success rate and types of middle ear and mastoid pathology. There has been much controversy abo...

CONCLUSION Retrograde mastoidectomy with soft-wall reconstruction is an effective technique that can be used to lower the recurrence rate of cholesteatoma in the pediatric population. OBJECTIVE To evaluate surgical outcomes of retrograde mastoidectomy when using soft-wall reconstruction in pediatric cholesteatoma. METHODS A total of 25 children underwent cholesteatoma removal surgery employ...