Alkaline phosphatase (ALP) in human choriocarcinoma cells (malignant trophoblasts) was characterized by its greater sensitivity to EDTA and L-leucine inhibition as compared with the placental isozyme. In addition, both the fully processed and the nonglycosylated forms of choriocarcinoma ALP migrated faster than the corresponding placental enzyme in sodium dodecyl sulfate-polyacrylamide gel elec...

•Methyl-piperidino-pyrazole downregulated phosphorylated estrogen receptor-? (S118).•Genistein further decreased the levels of receptor-?.•Genistein reduced proliferation JEG-3 human choriocarcinoma cells.•Genistein Ki-67 in cells. Background & aimsChoriocarcinoma is a malignant trophoblastic tumor. The phosphorylation at serine 118 (p-ER-s118) decreases cancer cell proliferation. However, effe...

It is just 100 years since Marchand [1] identified choriocarcinoma as a tumour arising from placental villous trophoblast. Earlier description of similar tumours failed to identify their tissue of origin. Gestational Trophoblastic Disease (GTD) is the terminological umbrella now used to span the spectrum of cellular proliferations ranging from villous forms of hydatiform mole through invasive m...

Choriocarcinoma is a very rare germinal testicular tumour and in literature its incidence has been reported to be 0.3% of all germinal testicular tumours. An important tumour marker is serum beta-hCG which not only helps in establishing diagnosis but also in assessing response to chemotherapy. In this study we present a case of testicular choriocarcinoma, who presented with abdominal pain, coug...

INTRODUCTION A choriocarcinoma is a malignant neoplasm normally arising in the gestational trophoblast, gonads and, less frequently, the retroperitoneum, mediastinum and pineal gland. Primary choriocarcinomas of the renal pelvis are extremely rare. CASE PRESENTATION We report a case of primary choriocarcinoma of the renal pelvis in a 38-year-old Greek woman of reproductive age, presenting wit...

Choriocarcinoma, a nonseminomatous germ cell tumor, is a rare type of testicular malignancy that tends to occur in young males. It is, however, exceedingly rare for choriocarcinoma to involve the GI tract. In this article, we present a rare case of a 31-year-old male, diagnosed with choriocarcinoma of the left testes, along with several metastases to distant sites. The patient presented with he...

Choriocarcinoma is a gestational trophoblastic tumor that mainly affects women of childbearing age. Cases of choriocarcinoma in postmenopausal women are exceptional. Through an observation and literature review, we propose to study the specific diagnosis and treatment features of this tumor in menopausal women. We report the observation of a pure uterine choriocarcinoma, which occurred in post-...

We describe a case of choriocarcinoma with multiple organ metastases after term delivery. A 43-year-old female was diagnosed as choriocarcinoma with metastases to the liver, lungs, marrow cavity, thoracic vertebra and brain, based on serum levels of β-human chorionic gonadotrophin (β-hCG), clinical symptoms, gynecological examination, PET/CT examination and medical histories. Fourteen courses o...

We present a case of upper gastrointestinal bleeding in an otherwise healthy 18-year-old man who presented with melena. Endoscopy revealed an ulcerated mass in the stomach and pathology confirmed this to be a malignant, poorly differentiated choriocarcinoma. Further imaging showed a left testicular mass with evidence of pulmonary, gastric, and brain metastases, and blood tests revealed an hCG l...

Abstract Background Pure ovarian choriocarcinoma can be gestational or nongestational in origin. Nongestational pure is extremely rare and the prognosis thought to worse than that of type patients with metastatic disease. We present a case poor which origin was identified as by DNA short tandem repeat (STR) analysis. Case presentation A nulliparous woman her thirties referred our hospital after...