Struchium sparganophora, (Linn.) Asteraceae is a culinary herb consumed in the western part of Nigeria and it is known to have a nutritive value. This study was carried out to assess its' effects on the hematopoietic parameters and its toxicity on the organ system of Wistar rats. The animals were randomly divided to five (5) groups. The group 1 (control) received distilled water equivalent to t...

Benzene has been considered as an occupational hematotoxin and leukemogen. The present study was conducted to determine the effects of oral administration of benzene on reproductive organs and testicular spermatogenesis in rats. Adult rats were divided into three weight matched groups (Gr. I-III) containing 6 each. Gr. I rats received vehicle only and served as control. Rats in Gr. II and III w...

The effects of high toxic doses of the anticancer drugs, etoposide and its phosphate derivative, BMY-40481, on the nervous system of female CD-1 mice were examined by light microscopy (LM) and transmission electron microscopy. Mice were euthanatized 4 wk following a single iv injection of either 0, 50, 100, or 150 mg/kg of BMY-40481 or 44 or 88 mg/kg of etoposide. Mice treated with 100 or 150 m...

The study was carried out to evaluate the neuropathological effect of sodium fluoride in hippocampus of albino rat. Healthy albino rats of Wistar strain weighing 100-200 g were divided in four groups. Group I was given 1 ml double distilled deionized water/kg body weight/day for forty days and kept as control. The remaining groups II, III and IV were treated with 100, 200 and 300 ppm of sodium ...

BACKGROUND The primary site of action of pregabalin, i.e. the α-2-δ subunit of the voltage-dependent calcium channel, is located at the dorsal root ganglion and dorsal horn of the spinal cord. Therefore, the epidural administration of pregabalin could have advantages over oral administration. However, the possibility of its neurotoxicity should be excluded before any attempt at epidural adminis...

The normal development of the brachial ventral horn of the frog Xenopus laevis and the response of the brachial ventral horn to complete forelimb extirpation at five developmental stages were assessed histologically. Differentiation of brachial ventral horn neurons occurred in pre-metamorphic tadpoles between stages 52/53 and 57. Mean cell number in the brachial ventral horn reached a peak of 2...

Earlier studies in this laboratory have dealt with the striking histological and chemical changes which occur in motoneurons of the spinal cord of the rhesus monkey after axon section and during the period of axon regeneration (l-3). The time course of the morphological changes has been analyzed, and the characteristics of hhese changes reviewed in a recent report (2). The evidence now at hand ...

bral grey matter was normal. The posterior borders of these lesions were formed by the caudate nuclei, the anterior parts of the internal capsules being spared. The lesions reached the parietal periventricular areas. The necrotic areas were characterised by extensive loss of myelin with myelin laden gitter cells. On both sides a substantial number of neurons in the ventromedial parts of the put...

background and objectives: acrylamide is a monomer which is formed in foodstuffs containing carbohydrates altered to asparagine during thermal processing. vitamin e is a component in human diet considered as the most effective lipid-soluble antioxidant found in the biological system. it prevents initiation of oxidative tissue damage. the aim of this study was to investigate the potential role o...

  Background and Objectives: Acrylamide is a monomer which is formed in foodstuffs containing carbohydrates altered to asparagine during thermal processing. Vitamin E is a component in human diet considered as the most effective lipid-soluble antioxidant found in the biological system. It prevents initiation of oxidative tissue...