نتایج جستجو برای: chromosome 14

تعداد نتایج: 471848  

Journal: :Journal of medical genetics 2003
K J Coveler V R Sutton C Knox-DuBois L G Shaffer

Uniparental disomy of chromosome 14 (UPD(14)) results in one of two distinct abnormal phenotypes depending upon the parent of origin. The discordance between the maternal and paternal UPD(14) phenotypes may result from overexpression and/or underexpression of one or more imprinted genes located on chromosome 14q. A cluster of imprinted genes has been identified and localised to 14q32. However, ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2009
Arthur Kwok Leung Cheung Hong Lok Lung Josephine Mun Yee Ko Yue Cheng Eric J Stanbridge Eugene R Zabarovsky John M Nicholls Daniel Chua Sai Wah Tsao Xin-Yuan Guan Maria Li Lung

Chromosome 14 allelic loss is common in nasopharyngeal carcinoma (NPC) and may reflect essential tumor suppressor gene loss in tumorigenesis. An intact chromosome 14 was transferred to an NPC cell line using a microcell-mediated chromosome transfer approach. Microcell hybrids (MCHs) containing intact exogenously transferred chromosome 14 were tumor suppressive in athymic mice, demonstrating tha...

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