Two general types of clonal chromosome abnormality are observed in de novo acute myeloid leukemia (AML): the unbalanced aberrations with visible gain or loss of chromosome material and the balanced aberrations without such visible gain or loss. AML can be induced by therapy with cytostatic drugs and radiation. The alkylating agents reacting directly with DNA induce AML which often presents as m...

Two general types of clonal chromosome abnormality are observed in de novo acute myeloid leukemia (AML): the unbalanced aberrations with visible gain or loss of chromosome material and the balanced aberrations without such visible gain or loss. AML can be induced by therapy with cytostatic drugs and radiation. The alkylating agents reacting directly with DNA induce AML which often presents as m...

The main objective of the present study was to develop an efficient and reliable probe to be routinely used for detection of chromosome 13 copy numbers by interphase FISH. To achieve this, a Yeast Artificial Chromosome (YAC) containing sequences specific for human 13q12 (744D11), was cultured and the whole yeast genomic DNA was extracted. The human insert within the isolated DNA was amplified b...

ABSTRACT Parodontidae is a relatively small group of Neotropical characiform fishes consisting three genera (Apareiodon, Parodon, and Saccodon) with 32 valid species. A vast cytogenetic literature available on Apareiodon but to date, there no data about Saccodon, genus that contains only species trans-Andean distribution. In the present study karyotype S. wagneri was described, based both conve...

Abstract Chromosome fusions threaten genome integrity and promote cancer by engaging catastrophic mutational processes, namely chromosome breakage–fusion–bridge cycles chromothripsis. are frequent in cells incurring telomere dysfunctions or those exposed to DNA breakage. Their occurrence therefore their contribution instability unchallenged is unknown. To address this issue, we constructed a ge...

Chronic myelogenous leukemia (CML) is a type of leukemia originating from hematopoietic stem cells characterized by unregulated proliferation of myeloid cells. Leukemic cells carry the chromosome, a translocation between one chromosome 9 and one chromosome 22. This chromosome has the fusion gene which consists of fragments of the breakpoint cluster region (BCR) and abelson murine leukemia (ABL)...

turner syndrome is a sex-chromosome disorder occurring in one out of 2500 female births and characterized by growth retardation, gonadal dysgenesis and cardiovascular anomalies. the 45, xo karyotype is the most frequent type of this disease. herein, we report on a 6-year-old girl with turner syndrome and 45, xo karyotype presenting with short stature. she had dextrocardia and hiatal hernia. to ...

Hurler syndrome also known as mucopolysaccharidosis type 1H (MPS-1H) or gargoylism is an autosomal recessive disorder due to defective gene which encodes for enzyme alpha L-iduronidase (IUDA) located on chromosome 4p16.3 (gene encoding protein iduronidase). In the present case, 4-year Down’s child with coarse facial features, hypothyroidism presented umbilical hernia. Clinical diagnosis of was ...

Abstract A karyotypic study was performed on 12 Iranian local onion (Allium cepa L.) populations. A number of mitotic cells at metaphase stage for each population were prepared. Chromosomes of suitable mitotic cells were counted and various parameters, including long arm (L), short arm (S), total length of chromosome (TL), relative length of chromosome (RL), arm ratio (AR), r-value, total chro...