Chronic lymphocytic leukemia/small lymphoma (CLL/SLL) is an indolent small B-cell neoplasm that may transform into a clinically aggressive disease, namely Richter syndrome, usually as diffuse large lymphoma. Besides, CLL/SLL encompasses increased risk of developing other secondary cancers, including variety T-cell lymphomas, often the anaplastic large-cell type or with cytotoxic phenotype. Here...

Abstract Prognostication in patients with chronic lymphocytic leukemia (CLL) is challenging due to heterogeneity clinical course. We hypothesize that constitutional genetic variation affects disease progression and could aid prognostication. Pooling data from seven studies incorporating 842 cases identifies two genomic locations associated time diagnosis treatment, including 10q26.13 (rs736456,...

OBJECTIVE To determine the frequency of various cytogenetic aberrations in newly diagnosed chronic lymphocytic leukemia (CLL) patients, and their detection rate by cytogenetic and fluorescent In situ hybridization (FISH) technique separately. STUDY DESIGN A case series. PLACE AND DURATION OF STUDY Clinical and Molecular Cytogenetics Laboratories, University of California, Los Angeles, USA, ...

1. dept. of hematology and medical oncology, kermanshah university of medical sciences, kermanshah, iran 2. students research committee, kermanshah university of medical sciences, kermanshah, iran 3. medical biology research center, kermanshah university of medical sciences, kermanshah, iran                                     corresponding author: masoud sadeghi, msc. tel: (+98) 9185960644 ema...

Microsatellites are important highly polymorphic genetic markers dispersed in the human genome. Using a panel of 22 (CA)n repeat microsatellite markers mapped to recurrent breakpoint cluster regions specifically involved in leukemia, we investigated 114 adult leukemias (25 acute lymphocytic leukemia [ALL], 32 acute myeloid leukemia [AML], 36 chronic lymphocytic leukemia [CLL], and 21 chronic my...

Ferroptosis is a newly defined programmed cell death (PCD) process with the hallmark of accumulation iron-dependent lipid peroxidation, which more immunogenic over apoptosis. shows great potential as therapeutic target against acute kidney injury (AKI), cancers, cardiovascular diseases, neurodegenerative and hepatic diseases. Accumulating evidence has highlighted that ferroptosis plays an unneg...

Background and purpose: Cytotoxic effects of Ligustrum vulgare leaves on HeLa cervical tumor cells suggested that extracts should be investigated as potential anticancer agents. Therefore, we examined a antileukemic activity methanolic fruit two types leukemia cells, MOLT-4 JVM-13, lymphocytes isolated from the blood 33 chronic lymphocytic (CLL) patients mononuclear leukocytes 18 healthy indivi...

Introduction. The mutational status of immunoglobulin heavy chain variable region genes (IGHV) is the most important prognostic factor in chronic lymphocytic leukemia (CLL). Furthermore, a significant narrowing IGHV gene repertoire found CLL and other lymphoproliferative diseases. Aim — to review publication data on diseases regarding their clinical significance. General information. Nucleotide...

Tim-3 is a negative immunoregulator in anti-tumor response, but its mechanism chronic lymphocytic leukemia (CLL) not yet clear. The aim of this study was to understand the role Galectin-9/Tim-3 signaling pathway regulation CD4+ T cell subsets CLL patients. Flow cytometry results showed that number Treg cells obviously increased, and there significant Treg/Th17 imbalance In addition, overexpress...

Introduction: Venetoclax has emerged as a breakthrough treatment which revolutionized the therapeutic paradigm of chronic lymphocytic leukemia (CLL). This is primarily attributed to efficacy venetoclax time-limited, chemo-free, therapy in field dominated by targeted agents given on continuous schedule. Furthermore, compelling clinical data support use combination with other hope preventing drug...