INTRODUCTION Chronic nonbacterial osteomyelitis (CNO) or chronic recurrent multifocal osteomyelitis (CRMO), is a very rare condition of unknown aetiology. It is characterised by focal sterile inflammatory disease with prolonged, self-limiting and recurrent episodes. CASE PRESENTATION We report the discovery of this very rare disease following a mandibular abscess in a 10-year-old female. We i...

Results Fifty six patients were included: 17 Cryopyrin-Associated Periodic Syndromes (CAPS), 4 TNF-Receptor-Associated Periodic fever Syndrome (TRAPS), 5 Hyperimmunoglobulinaemia D with periodic fever Syndrome (HIDS), 18 Familial Mediterranean Fever (FMF), 6 Chronic Recurrent Multifocal Osteomyelitis (CRMO), 2 Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis (SAPHO) syndrome and 4 Behçet’s D...

BACKGROUND CRMO is characterized by chronic bone pain of recurrent nature. The onset is usually at the beginning of the second decade of life. Bony lesions may be visible on radiographs, although sometimes a CT or MRI scan is necessary to visualise them. The aim of study was analyse symptoms, diagnostic difficulties and results of accessory investigations in patients suffering from CRMO. MATE...

Introduction Chronic recurrent mutifocal osteomyelitis (CRMO) (OMIM-number-259680), a rare form of autoinflammatory disease of the bone marrow of unknown aetiology, which takes a sub-acute course. First described in 1972 by Gideon et al, CRMO is primarly a diagnosis of exclusion as suggested by negative bone biopsy for neoplasms and negative bone culture to rule out infectious causes. In our ca...

We report a case of a 13-year-old girl with chronic recurrent multifocal osteomyelitis (CRMO) who developed severe arthritis in four different joints within the first year from the onset of the disease. Her multiple vertebrae lesions showed significant amelioration after a 2-month treatment with prednisolone. In parallel, the initial severe symmetrical arthritis of both knees showing overt syno...

Chronic Non-Bacterial Osteitis (CNO) was first described in 1972 by [1]. This condition consists of an Autoinflammatory bone disorder that results in bone lesions and is often seen in young children (approximately 7-12 years old) [2]. Patients may suffer from a single to multiple bone lesions that may selfresolve, persist, and/or reoccur [3]. When patients have the most severe manifestation of ...