Ototoxicity is known to cause permanent loss of vestibule function through degeneration of sensory hair cells (HCs). However, functional recovery has been reported during washout after chronic ototoxicity, although the mechanisms underlying this reversible dysfunction are unknown. Here, we study this question in rats chronically exposed to the ototoxic compound 3,3′-iminodipropionitrile (IDPN)....

This study was performed following favorable results from a previous research, which studied the response of acute vestibular patients to the rotatory maneuver, to investigate the effects of the rotatory maneuver on chronic vestibular patients. In an attempt to normalize the patient’s directional preponderance (DP), and hence their vestibular symptoms, the study was designed to reduce the imbal...

This study was performed following favorable results from a previous research, which studied the response of acute vestibular patients to the rotatory maneuver, to investigate the effects of the rotatory maneuver on chronic vestibular patients. In an attempt to normalize the patient’s directional preponderance (DP), and hence their vestibular symptoms, the study was designed to reduce the imbal...

OBJECTIVE The aim of this study was to assess the subjective visual vertical in patients with bilateral vestibular dysfunction and to propose a new method to analyze subjective visual vertical data in these patients. METHODS Static subjective visual vertical tests were performed in 40 subjects split into two groups. Group A consisted of 20 healthy volunteers, and Group B consisted of 20 patie...

The authors studied patients with diabetes and complaints of dizziness to determine whether peripheral neuropathy or inner ear dysfunction was more likely to disturb balance. Quantitative testing showed that the majority failed to maintain balance in vestibular-related conditions and had normal equilibrium scores in conditions relying on somatosensory input. Vestibular dysfunction should be an ...

The purpose of this study was to investigate the effects of various levels of vestibular function on balance in two, free-standing rhesus monkeys. We hypothesized that postural control strategy depended on the severity of vestibular damage. More specifically, that increased muscle stiffness (via short-latency mechanisms) was adequate to compensate for mild damage, but long-latency mechanisms mu...

Usher syndrome (USH) is an autosomal recessive disease characterized by hearing loss, retinitis pigmentosa (RP), and, in some cases, vestibular dysfunction. It is clinically and genetically heterogeneous and is the most common cause underlying deafness and blindness of genetic origin. Clinically, USH is divided into three types. Usher type I (USH1) is the most severe form and is characterized b...

Obstructive sleep apnea (OSA) and dizziness are common conditions observed in the general population, several epidemiological studies have reported an association between OSA dizziness. Vestibular dysfunction, autonomic instability, cerebellar degeneration secondary to recurrent hypoxia implicated as mechanisms underlying patients with OSA. Moreover, is a risk factor for many diseases associate...

CHARGE syndrome is a rare human disorder caused by mutations in the gene encoding chromodomain helicase DNA binding protein 7 (CHD7). Characteristics of CHARGE are varied and include developmental ear and hearing anomalies. Here we report a novel mouse model of CHD7 dysfunction, termed Looper. The Looper strain harbours a nonsense mutation (c.5690C>A, p.S1897X) within the Chd7 gene. Looper mice...

The vestibular system is responsible for keeping an animal oriented with respect to gravity. It is a sensory system that maintains the position of the eyes, body, and limbs in reference to the position of the head. Proper interpretation of neurologic deficits and precise neuroanatomic localization are essential to diagnose and prognosticate the underlying disorder. Neurologic examination can co...