نتایج جستجو برای: cigarette smoking extracts cse

تعداد نتایج: 195621  

2014
Xiang Wang Ya-jie Qian Qian Zhou Pei Ye Ning Duan Xiao-feng Huang Ya-nan Zhu Jing-jing Li Li-ping Hu Wei-yun Zhang Xiao-dong Han Wen-mei Wang

Cigarette smoke exposure is associated with increased risk of various diseases. Epithelial cells-mediated innate immune responses to infectious pathogens are compromised by cigarette smoke. Although many studies have established that cigarette smoke exposure affects the expression of Toll-liked receptor (TLR), it remains unknown whether the nucleotide-binding oligomerization domain-containing p...

2017
Zongxian Jiao Jiachen Chang Jing Li Dengmei Nie Huijuan Cui Dongfang Guo

Cigarette smoking is a primary risk factor for chronic obstructive pulmonary disease (COPD), as it damages epithelial cells through a variety of mechanisms. Sulforaphane (SFN) is an antioxidant agent, which exerts protective effects against cell damage by activating the nuclear factor erythroid 2 like 2 (NFE2L2; Nrf2). The present study was undertaken to investigate the effects and underlying m...

Journal: :Medical science monitor : international medical journal of experimental and clinical research 2010
Daniella R Duarte Marcos F Minicucci Paula S Azevedo Fernanda Chiuso-Minicucci Beatriz B Matsubara Luiz S Matsubara Alvaro O Campana Sergio A R Paiva Leonardo A M Zornoff

BACKGROUND To investigate the effect of lisinopril on cardiac remodeling induced by smoking. MATERIAL/METHODS Rats were allocated into 3 groups: group CON (n=8): control; group CSE (n=8): cigarette smoke exposure; group CSE-LIS (n=8): exposed to tobacco smoke and treated with lisinopril. RESULTS After 2 months, the tail systolic pressure was lower in CSE-LIS (CON=116 +/-27 mm Hg, CSE=126+/-...

Journal: :Neurotoxicology and teratology 2013
Robyn M Amos-Kroohs Michael T Williams Amanda A Braun Devon L Graham Cynthia L Webb Todd S Birtles Robert M Greene Charles V Vorhees M Michele Pisano

Although maternal cigarette smoking during pregnancy is a well-documented risk factor for a variety of adverse pregnancy outcomes, how prenatal cigarette smoke exposure affects postnatal neurobehavioral/cognitive development remains poorly defined. In order to investigate the cause of an altered behavioral phenotype, mice developmentally exposed to a paradigm of 'active' maternal cigarette smok...

Journal: :Molecules 2012
Wenbo Liu Xiaobin Tan Luan Shu Hanyan Sun Jie Song Ping Jin Siming Yu Min Sun Xiaobin Jia

Cigarette smoking is the main cause of chronic obstructive pulmonary disease and lung cancer. The present study was aimed to explore the chemopreventive effect of ursolic acid (UA) on these diseases. In the CSE treated normal human bronchial epithelial cell model, UA alleviated cytotoxicity caused by CSE, recovered the intracellular redox balance, and relieved the stimulation of external delete...

Journal: :Journal of immunology 2012
Fen-Fen Li Jian Shen Hui-Juan Shen Xue Zhang Rui Cao Yun Zhang Qiu Qui Xi-Xi Lin Yi-Cheng Xie Lin-Hui Zhang Yong-Liang Jia Xin-Wei Dong Jun-Xia Jiang Meng-Jing Bao Shanshan Zhang Wen-Jiang Ma Xi-Mei Wu Huahao Shen Qiang-Min Xie Yuehai Ke

Cigarette smoke (CS), the major cause of chronic obstructive pulmonary disease, contains a variety of oxidative components that were implicated in the regulation of Src homology domain 2-containing protein tyrosine phosphatase 2 (Shp2) activity. However, the contribution of Shp2 enzyme to chronic obstructive pulmonary disease pathogenesis remains unclear. We investigated the role of Shp2 enzyme...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2007
Elizabeth H Sidle Richard Casselman Graeme N Smith

Cigarette smoking is associated with systemic oxidative stress leading to an upregulation of antioxidant systems [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and heme oxygenase (HO)] in some tissues, but the response in the human placenta is unknown. The aim of this study was to determine the effect of cigarette smoke exposure on placental antioxidant expression in...

Journal: :Oncology reports 2016
Xue-Jiao Lv Yan-Wei Du Yu-Qiu Hao Zhen-Zhong Su Lin Zhang Li-Jing Zhao Jie Zhang

Cigarette smoking has been shown to be the most significant risk factor for lung cancer. Recent studies have also indicated that RNA-binding motif protein 5 (RBM5) can modulate apoptosis and suppress tumor growth. The present study focused on the role of RBM5 in the regulation of cigarette smoke extract (CSE)-induced transformation of bronchial epithelial cells into the cancerous phenotype and ...

2016
Jeffrey S. Bourgeois Jeeva Jacob Aram Garewal Renata Ndahayo Julia Paxson

Cellular exposure to cigarette smoke leads to an array of complex responses including apoptosis, cellular senescence, telomere dysfunction, cellular aging, and neoplastic transformation. To study the cellular response to cigarette smoke, a common in vitro model exposes cultured cells to a nominal concentration (i.e. initial concentration) of soluble cigarette smoke extract (CSE). However, we re...

2011
Patrick Geraghty Alison Wallace Jeanine M D’Armiento

PURPOSE Cigarette smoke is the major risk factor associated with the development of chronic obstructive pulmonary disease (COPD). Recent studies propose a link between endoplasmic reticulum (ER) stress and emphysema, demonstrated by increased ER stress markers under smoking conditions. Here, we investigate whether cigarette smoke-induced ER stress is cell specific and correlates with acute and ...

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