CONTEXT Distinction between primary lung carcinomas and metastases from other sites, especially the urinary tract, is a common diagnostic dilemma. As urothelial carcinomas can demonstrate a broad range of morphology and frequently demonstrate squamous differentiation, discerning metastatic urothelial carcinoma to the lung from primary pulmonary squamous cell carcinoma can be challenging. OBJE...

Renal carcinomas are a heterogeneous group of tumors, difficult to classify and identify precisely. Since their prognosis depends very much upon their type, precise diagnosis might mean the difference between therapeutic success and patient death. Cytokeratins are particularly useful for the identification of the epithelial nature of the tumors, because their expression is maintained even in po...

colorectal cancer most commonly metastasizes to the liver and lung. metastatic colon carcinoma (mcc) to the breast is extremely rare. krukenberg tumor is an uncommon metastatic tumor of the ovary. case presentation: a 38 years woman presented with abdominal pain. in evaluation colon cancer was diagnosed at stage 3. folfox chemotherapy was done. after one year she developed krukenberg tumor. few...

Symptomatic gastrointestinal metastasis from lung malignancy is rarely reported. In this report, we present a case of lung adenocarcinoma with acute abdominal pain from small bowel perforation. The patient underwent small bowel resection and the final diagnosis was metastatic adenocarcinoma originating from lung. Immunohistochemistry was positive for thyroid transcription factor-1 and cytokerat...

On histological examination, mitoses were easily found: 3/10 fields and there were multiple foci of necrosis. On immunohistochemistry, the tumor cells were positive for CD31 and negative for: cytokeratine AE1-AE3, CK7,CK5-6,CK20,EMA,P63,PSA,CDX2,PSO4S, chromogranine A,PS100,CD34,Actine, Desmine, Caldesmone, CD117,DOG1. Post Irradiation Pelvic Sarcoma 8 Years after Treatment for Adenocarcinoma f...

This paper presents the application of 'TissueQuant' algorithm which is a unique approach to assess color shade similarities to quantify the extent of staining to arrive at a diagnosis. This is done by assigning scores to different shades of a particular color based on how close the shade is to a reference color. This approach is applied to the quantification of ck7 stain for diagnosi...