نتایج جستجو برای: clear plaques
تعداد نتایج: 216254 فیلتر نتایج به سال:
Alzheimer's disease (AD) is characterized by senile plaques and neurodegeneration although the neurotoxic mechanisms have not been completely elucidated. It is clear that both oxidative stress and inflammation play an important role in the illness. The compound curcumin, with a broad spectrum of anti-oxidant, anti-inflammatory, and anti-fibrilogenic activities may represent a promising approach...
The adhesion molecule P-selectin (CD62P) is of interest because of its role in modulating interactions between blood cells and the endothelium, and also because of the possible use of the soluble form as a plasma predictor of adverse cardiovascular events. Although present on the external cell surface of both activated endothelium and activated platelets, it now seems clear that most, if not al...
Reactive astrogliosis, a complex process characterized by cell hypertrophy and upregulation of components of intermediate filaments, is a common feature in brains of Alzheimer's patients. Reactive astrocytes are found in close association with neuritic plaques; however, the precise role of these glial cells in disease pathogenesis is unknown. In this study, using immunohistochemical techniques ...
Plaque disruption generally occurs in the setting of a thin cap fibroatheroma morphology, characterized by a large necrotic lipid core, intense macrophage infiltration, microcalcifications, and a thin fibrous cap, but it has recently become clear that characterization of plaque risk based on anatomy alone is necessary but not sufficient to predict those highrisk plaques likely to destabilize an...
Plaque disruption generally occurs in the setting of a thin cap fibroatheroma morphology, characterized by a large necrotic lipid core, intense macrophage infiltration, microcalcifications, and a thin fibrous cap, but it has recently become clear that characterization of plaque risk based on anatomy alone is necessary but not sufficient to predict those highrisk plaques likely to destabilize an...
OBJECTIVES The purpose of this study was to investigate whether stent-based delivery of an inhibitor of mammalian target of rapamycin (mTOR) can selectively clear macrophages in rabbit atherosclerotic plaques. BACKGROUND Current pharmacologic approaches to stabilize atherosclerotic plaques have only partially reduced the incidence of acute coronary syndromes and sudden death. Macrophages play...
Background: Several treatments have been proposed to control Multiple Sclerosis (MS). Fingolimod is the first oral medication for the disease that was approval by Food and Drug Administration American (FDA) since 2010 and is produced in Iran from October 2013. The aim of this study was evaluation of the effect of fingolimod on the number of brain plaque in multiple sclerosis patients before and...
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