This paper reports the efficacy results of the randomized, placebo-controlled, field trial of SPf66 malaria vaccine in Costa Marques, Rondonia, Brazil. This region is characterized by the seasonal distribution of Plasmodium falciparum and P. vivax infections, and the recent occupation by migrants from nonendemic areas. A total of 800 individuals of both sexes, ranging in age from seven to 60 ye...

Reimbursement lists: A. Generics/other less expensive drugs with good cost-effectiveness: 90% reimbursement B. Essential but more expensive drugs: 50% reimbursement C. Specified conditions, prescribed by specialists: C1: Ambulatory care medicines for severe/ chronic diseases C2: Hospital only C3: A+B plus additional OTC products limited to persons <18 years old, students, pregnant women and you...

BACKGROUND Biobanks increasingly presume long-term storage of biomaterials and data that shall be used for future research projects which are today unspecified. Appropriate consent documents for sample donors must therefore explain the breadth of consent and other elements of the biobank governance framework. Recent reviews demonstrated high variability in what issues these documents mention or...

BACKGROUND The purpose of this article is to report on the quality of the existing evidence base regarding the effectiveness of clinical pathway (CPW) research in the hospital setting. The analysis is based on a recently published Cochrane review of the effectiveness of CPWs. METHODS An integral component of the review process was a rigorous appraisal of the methodological quality of publishe...

Peer teaching by medical students is increasingly consid- ered an effective and efficient instructional modality with value for both teachers and learners. In 2012, twelve senior medical students participated in an inaugural, four-week Medical Education Elective at The Alpert Medical School of Brown University. The first week emphasized education theory and skills. During the remaining three we...

BACKGROUND Poverty undermines the adherence of patients to tuberculosis treatment. A pragmatic cluster randomized controlled trial was conducted to investigate the extent to which economic support in the form of a voucher would improve patients' adherence to treatment, and their treatment outcomes. Although the trial showed a modest improvement in the treatment success rates of the intervention...