1. Executive Summary 531 2. Introduction 532 3. Definition of Clinical Pharmacology 533 4. History of Clinical Pharmacology 533 5. The Global Medicine Scene 534 6. Roles of Clinical Pharmacology 535 6.1 Research 535 6.2 Teaching 537 6.3 Patient care 540 6.4 Pharmaceutical industry 542 6.5 Governments 544 7. Organization 546 8. The Relationship with Other Drug Experts 547 9. Emerging Roles of Cl...

Deoxycoformycin (DCF) is an inhibitor of adenosine deaminase (ADA). Twenty-one courses of DCF were administered to 13 patients ranging in age from 15 to 78 yr. Eight patients had T-cell disorders, and five patients had non-T-cell malignancies. The i.v. bolus dose was escalated from 5 to 30 mg/sq m/day, and the duration of the courses ranged from 1 to 5 days. The DCF plasma half-life ranged from...

(Pp. l-xvi+ 1-904. 120s). London: Bailliere, Tindall & Cassell, 1969. NINE years have elapsed since the last edition of Mayer-Gross, Slater and Roth's Clinical Psychiatry was published. During that time it maintained its position both as a standard text for graduate students of Psychiatry and as one of he major reference books on the subject. This new edition has enhanced its stature and has pr...

THIS is the most recent of a series of general practitioner handbooks covering medical specialities and designed to be practical and short in compass. Dr. Golding is an experienced author (and rheumatologist) and has put a great deal of his widely based knowledge into this manual. Recognised difficulties in the classification, diagnosis and therapy of the common rheumatic states are presented l...

Objectives: The aim of this study was to investigate linear and nonlinear properties of tremor time series. To this end, we applied linear (second order) and nonlinear (higher order) spectral and cross-spectral analysis to 58 Electroencephalographic (EEG) and Electromyographic (EMG) tremor recordings of seven essential and five Parkinsonian Tremor patients. Methods: Second and third order spect...