OBJECTIVES To compare clinical and MRI parameters between patients with clinically isolated syndrome and those converting to clinically definite multiple sclerosis within 2 years, to identify volumetric MRI predictors of this conversion and to assess effect of early relapses. METHODS The SET study comprised 220 patients with clinically isolated syndrome treated with interferon beta (mean age,...

The authors present the case of a 50 years old woman who during 3 years had a transient right limbs palsy, and numerous episodes of unilateral/bilateral optic neuropathy. The CSF and MRI examinations did not sustain the diagnosis of multiple sclerosis (MS). After 2 years from the onset, she presented bilateral trigeminal neuropathy, and after 9 months the anti-SS-A and anti SS-B antibodies were...

Anti-myelin oligodendrocyte (MOG)-positive cases have a variable clinical presentation. MOG autoantibodies are associated with acute disseminated encephalomyelitis, multiple sclerosis, clinically isolated syndrome, neuromyelitis optica, optic neuritis, and transverse myelitis. Our patient had bilateral neuritis tetraparesis. Cranial magnetic resonance imaging (MRI) showed leptomeningeal contras...

#### Notable in Neurology This Week This issue features an article that investigates the effects of changes to multiple sclerosis (MS) diagnostic criteria over time on treatment and outcome patients with clinically isolated syndrome; another compares characteristics perimenstrual nonperimenstrual migraine attacks women migraine. A review discusses main epilepsy phenotypes associated monogenic ...