Histoid lepro sy, originally described by Wade in 1960 (1 2) is generally regarded as a distinct clinico-pathological entity. It presents as cutaneous or subcutaneous nodular and / or plaque-like lesions arising from apparently normal skin. The lesions are characterized, histologically , by tumorous collections. of spindle-shaped cells arranged in a crisscross fashion giving them a resemblance ...

Two factors have stimulated the present intense investigation of acrylamide neurotoxicity. These are the health hazard accompanying the vast and increasing industrial production of acrylamide, and the promise of illuminating the mechanism of dying-back disease in the human nervous system by employing acrylamide as an experimental tool. The present paper discusses the industrial uses of acrylami...

malignant melanoma is a potentially aggressive tumor of melanocytic origin. primary oral malignant melanoma is a rare neoplasm, accounting for 0.5% of all oral malignancies. the present case occurred in a 60‑year‑old female patient, as a pedunculated growth involving the palate and alveolar ridge and histologically showing a desmoplastic differentiation. the article discusses the distinct clini...

The primary goal of breast cancer classification is to provide information that can guide the treatment of patients and be useful in prognostication. Traditionally, there is a wide variation in the morphology of breast cancer, and some subtypes and variants show typical clinico-pathologic correlations. Recent information on the molecular characteristics and phenotypes of human breast cancer has...

OBJECTIVE Neuroendocrine carcinomas (NECs) are rare neoplasms with an increasing incidence. Oncogenetic pathways of colorectal NEC are still poorly understood, and no treatment standards are available for these rare tumors. METHODS We analyzed retrospectively the clinical records and histology of 12 patients with colorectal NEC. KRAS and BRAF mutations were investigated after the dissection o...

A clinicopathologic study of 51 cases of mitral stenosis with intracardiac mural thrombi is presented with particular reference to the locations of these thrombi and their relationship to the associated thromboembolic phenomena. In 27 cases the thrombi were present only in the left side of the heart, in 15 cases they were in both sides of the heart, and in 9 cases they were present only in the ...

Introduction: Exfoliative dermatitis is an extreme state of skin irritation resulting in extensive erythema and or scaling of the body. More than 90% of skin surface involvement is considered as a salient pre-requisite to make a clinical diagnosis of exfoliative dermatitis. Histopathology aids in the diagnosis of many cases of exfoliative dermatitis. Purpose: Exfoliative dermatitis can be cause...