Oral multikinase inhibitors (MKI), such as sorafenib, inhibit the activation of tyrosine kinases and ultimately suppress tumor growth angiogenesis. Hand-foot syndrome (HFS) is most common side effect MKI wherein typical symptoms are tender blisters, cracks erythematous edematous lesions in palms soles. HFS not life-threatening, meanwhile severe cases impair quality life because pain reduced act...

Scientific knowledge is constantly expanding, and needs are changing; therefore, efforts must be made to adapt the treatment of leprosy and the manner in which it is implemented to the newly identified needs. Because an effective vaccine against leprosy remains to be identified, multidrug therapy (MDT) is the only tool available for leprosy control. At present, therefore, the priority is to mak...

Sir, Granuloma faciale (GF) is a rare, but distinct in ̄ammatory dermatosis of unknown origin diagnosed on a combination of clinical and histopathological ®ndings. The clinical presentation may be very variable and can simulate a great variety of dermatosis. The treatment is not well established and in many cases may be unsatisfying and frustrating. We report here a case of disabling and dis®gur...

The history of leprosy in our country begins in the colonial days, even though many authors have tried to demonstrate that this illness existed among the natives . These theories have been refuted, as for instance, by Charlevoix in his book 'History of the Island' , where he refers to leprosy as an illness 'only found in the city' . In other words, his remark suggests that leprosy did not exist...

The review presents up-to-date data from 88 publications devoted to the short-course regimens of multiple drug resistant tuberculosis treatment and describes characteristics most effective drugs – bedaquiline, linezolid, delamanid, clofazimine. Information is also provided on additional properties drugs, i.e. modulation key immune response immunometabolic processes that underlie a new approach ...

Abstract Leprosy is the prototype of a biblical disease. Without an effective cure, it was deemed ‘curse’ for millennia. It infection caused by Mycobacterium leprae and lepromatosis. With affinity peripheral skin (due to lower temperatures), rash common presenting feature. A tropism infiltrate neural tissue causes reduction in sensation leading repeated injury, disfigurement. Affected individua...