The effects of clonidine on substance P (SP) binding was investigated using rat brain and spinal cord membrane preparations preincubated with various concentrations of clonidine. [3H]SP specific binding in the spinal cord was significantly decreased with 10(-4) M clonidine, but no effect on binding was seen in the brain. Scatchard analysis of SP binding indicated that Bmax was significantly dep...

conclusions there were no statistical differences between oral clonidine and intravenous lidocaine regarding attenuation of hemodynamic responses after tracheal intubation in controlled hypertensive patients, although the rate of complications including mouth dryness, bradycardia, and orthostatic hypotension was significantly higher in the clonidine group before induction of anesthesia. results...

1. Clonidine (6 mg of base/l of water) was given as drinking fluid to normotensive rats or rats with established or early hypertension. 2. Spontaneous hypertensive rats (6 months old: average dose of clonidine, 0.6 mg 24 h-1 kg-1) showed a sustained fall in blood pressure over 3 weeks. 3. The same clonidine solution given for 6 weeks to two-kidney Goldblatt rats with early-stage hypertension (a...

We have conducted a double-blind, randomized study in two groups of 20 patients each, undergoing hip surgery during spinal anaesthesia, to compare the incidence of urinary retention after spinal morphine or clonidine. Patients received 0.5% spinal bupivacaine 15 mg combined with either clonidine 75 micrograms or morphine 0.2 mg. After operation, patients were examined for micturition, bladder d...

objective: withdrawal symptoms are a main reason of continuous use of opioid. this study compares the efficacy of augmentation of amantadine with clonidine in decreasing opioid withdrawal symptoms. methods: this double-blind randomized clinical trial was carried out in the detoxification and rehabilitation inpatient ward at razi hospital, tabriz, iran during 2012. the patients were randomly ass...

In infant rats, administration of the alpha2 adrenoceptor agonist clonidine simultaneously evokes ultrasound production and bradycardia. In this study the authors examined in 8-day-old rats whether these 2 responses to clonidine are causally related. In Experiment 1 pups were pretreated with saline or prenalterol (0.1 or 1.0 mg/kg), a beta1 adrenoceptor agonist that increases cardiac rate, foll...

A series of six fullerene-linker-fullerene triads have been prepared by the stepwise addition of the fullerene cages to bridging moieties thus allowing the systematic variation of fullerene cage (C60 or C70) and linker (oxalate, acetate or terephthalate) and enabling precise control over the inter-fullerene separation. The fullerene triads exhibit good solubility in common organic solvents, hav...

Fullerene graphs are 3-connected 3-regular planar graphs with only pentagonal and hexagonal faces. We show that the diameter of a fullerene graph G of order n is at least √ 24n−15−3 6 and at most n/5 + 1. Moreover, if G is not a (5, 0)-nanotube its diameter is at most n/6+5/2. As a consequence, we improve the upper bound on the saturation number of fullerene graphs. We also report an improved l...

A Fullerene with pentagons, hexagons, and heptagons is considered. The number of carbons is 458. It contains 8 heptagonal rings, 21 pentagons, and 212 hexagons. Keywords-component; fullerene; heptagon; pentagon adjacency penalty rule; fullerene with many carbons

The effect of clonidine (average 0.24 mg/day) and propranolol (average 105 mg/day) on home blood pressure readings in 16 patients with borderline hypertension was investigated in a randomized, double-blind, placebo crossover design. Patients could detect small but significant decreases of blood pressure with both active compounds (-8/-5 with propranolol and -11/-7 with clonidine). The larger me...