BACKGROUND Human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) is a major public health problem in sub-saharan Africa. Cytomegalovirus (CMV) has been reported to enhance HIV replication and accelerate the progression of HIV infection to AIDS. OBJECTIVE This study reports on the high seropositivity of immunoglobulin (Ig) G and M antibodies against CMV and the risk factor...

Infection by human cytomegalovirus (CMV) elicits a strong humoral immune response and robust anti-CMV antibody production. Diagnosis of virus infection can be carried out by using a variety of serological assays; however, quantification of serum antibodies against CMV may not present an accurate measure of a patient's ability to control a virus infection. CMV strains that express green fluoresc...

BACKGROUND Elevated levels of antibodies to Cytomegalovirus (CMV) have been associated with cognitive impairment, but the quantitative relationship between CMV antibody levels and domains of cognitive functioning in younger adults has not been established. METHODS We measured IgG class antibodies to Cytomegalovirus in 521 individuals, mean age 32.8 years. Participants were selected for the ab...

Objective: Cytomegalovirus (CMV) is a virus that can be transmitted to a developing child before birth. For most healthy persons who acquire CMV after birth, there are few symptoms. Once a person becomes infected, the virus remains alive, but usually dormant within that person’s body for life. There are two different types of infection: primary CMV and recurrent CMV infection. Primary infection...

BACKGROUND Cytomegalovirus (CMV) is a common cause of congenital infection worldwide and infants with symptomatic congenital CMV (cCMV) infection are at significantly increased risk of developing adverse long-term outcomes. This study aimed to determine the prevalence of cCMV infections in symptomatic infants under 3 weeks in Tehran, IRAN and to evaluate the usefulness of serologic markers in t...

Abstract Cytomegalovirus (CMV) is a top priority in vaccine development due to the high burden of disease immunocompromised populations and congenitally infected infants. Evidence suggests that CMV-specific Fc-mediated antibody effector responses, such as dependent cellular phagocytosis cytotoxicity, are key for prevention multiple CMV outcomes. However, human expresses three Fcγ receptors have...

Congenital cytomegalovirus (CMV) infection is a leading cause of hearing, cognitive, and motor disability in children for which medical science has yet to provide prevention or cure. Although vaccines aimed at prevention of congenital infection are being developed, there are significant challenges to be overcome and it could easily be a decade or longer before a CMV vaccine is licensed for prev...

The source of a fever of unknown origin (FUO) and watery diarrhea in a 63-yr-old female with a history of disturbance of consciousness due to moyamoya disease was examined. Fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET), colonoscopy, blood analysis, and determination of cytomegalovirus (CMV) antigenemia were performed. FDG was found to be accumulated in the wall of a dila...

A sensitive and reproducible enzyme-linked immunosorbent assay (ELISA) is described for the detection of immunoglobulin M and antibodies with specifity for human cytomegalovirus (CMV) early (CMV-EA) and late (CMV-LA) antigens. The emphasis is on the production of high-quality CMV antigens, CMV-EA and CMV-LA separately, and conditions for their application in the ELISA. The induction of CMV-EA a...