Becker's naevus is an acquired persistent asymmetrical area of skin pigmentation, sometimes showing evidence of increased androgen sensitivity, and colocalizing with other developmental anomalies. We report a 30-year-old woman with clinical findings compatible with Becker's naevus on her right breast accompanied with hypoplasia of ipsilateral breast.

Intraventricular haemorrhage (IVH) is an extremely rare and poorly described complication of central nervous system Tuberculosis (CNS-TB). In this study, we report the case a 42-year-old man who presented with weakness left hemibody diffuse headache, altered consciousness associated fever. No notion contagion was noted. Brain computed tomography (CT) showed hematoma in occipital horns lateral v...

Mitochondrial-dependent (intrinsic) programmed cell death (PCD) is an essential homoeostatic mechanism that selects bioenergetically proficient cells suitable for tissue/organ development. However, the link between mitochondrial dysfunction, intrinsic apoptosis and developmental anomalies has not been demonstrated to date. Now we provide the evidence that non-canonical mitochondrial dependent a...

RIEGER'S dysgenesis mesodermalis iridis et corneae, caused by a faulty differentiation in the anterior segment, is not limited to the mesodermal structures of the eye, but demonstrates a range of ectodermal anomalies as well. This is why Hagedoorn (1937) suggested the term "dysgenesis mesostromalis", stressing the frequent occurrence of ectodermal developmental anomalies of the iris and lens, c...

Congenital anomalies are a significant burden on human health. Understanding the developmental origins of such anomalies is key to developing potential therapies. The Human Developmental Biology Resource (HDBR), based in London and Newcastle, UK, was established to provide embryonic and fetal material for a variety of human studies ranging from single gene expression analysis to largescale geno...

This article discusses the risk assessment of a health information system. A case study was conducted at the South Western Sydney Area Health Service to examine the potential risks of the Maternal and Infant Network (MINET) health information system using Failure Mode Effect Analysis (FMEA). FMEA was conducted by utilising safety attributes identified by the authors. Potential failure modes of ...

Müllerian anomalies are very common, and a frequent cause of infertility. The most used classification system until now, proposed by the American Society for Reproductive Medicine in 1988, categorizes comprehensively uterine anomalies but fails to classify defects of the cervix or vagina. This is based on a developmental theory that postulates that müllerian duct fusion is unidirectional, begin...