Alternative pre-mRNA splicing provides an effective means for expanding coding capacity of eukaryotic genomes. Recent studies suggest that co-expression of different splice isoforms may increase diversity of RNAs and proteins at a single-cell level. A pertinent question in the field is whether such co-expression is biologically meaningful or, rather, represents insufficiently stringent splicing...

‎Let $X$ be a real normed  space, then  $C(subseteq X)$  is  functionally  convex  (briefly, $F$-convex), if  $T(C)subseteq Bbb R $ is  convex for all bounded linear transformations $Tin B(X,R)$; and $K(subseteq X)$  is  functionally   closed (briefly, $F$-closed), if  $T(K)subseteq Bbb R $ is  closed  for all bounded linear transformations $Tin B(X,R)$. We improve the    Krein-Milman theorem  ...

BACKGROUND New Zealand's health system has long been seen as providing highly fragmented, poorly co-ordinated services to service users. A continuing policy challenge has been how to reduce such fragmentation and achieve more 'integrated' care, that is, 'co-ordinated' care that provides a 'smooth and continuous' transition between services, and a 'seamless' journey as service users receive heal...

Platelets are involved in the maintenance of haemostasis but their inappropriate activation leads to thrombosis, a principal trigger for heart attack and ischaemic stroke. Although platelets circulate in isolation, upon activation they accumulate or aggregate together to form a thrombus, where they function in a co-ordinated manner to prevent loss of blood and control wound repair. Previous rep...

The co-ordinated development of ICTs within the HEI context is particularly problematic. The HEI provides a setting where there are numerous interest groups and strong organisational cultures. An often-used metaphor is that universities are like collections of fiefdoms where barons (and baronesses) are in charge of their own, independent realms, and vigorously defend their territories. It would...