Dear Editor, We read with great interest the recent article by Dudley and associates on early venous thromboembolic event (VTE) prophylaxis in traumatic brain injury (TBI) with lowmolecular-weight heparin (LMWH; Dudley, 2010). In that study the authors investigated the occurrence and timing of VTE, the symptomatic expansion of intracranial hemorrhages while on VTE prophylaxis, and the efficacy ...

Human blood at physiological conditions is kept as fluid through precise system called homeostasis, if damage to the vessel, causing the system will be restored by vessel wall. Cases no regulation or homeostasis disorders, thrombosis (intravascular coagulation) or bleeding occur. In normal conditions, the secretion of vascular endothelial heparin-like and trmbomodulin molecules prevent blood co...

chédiak-higashi syndrome is a rare autosomal recessive congenital immunodeficiency mainly characterized by a condition called oculo-cutaneous albinism. the affected subjects have light-colored hair, vision problems, blood clotting (coagulation) abnormalities and in adulthood varying neurologic disorders. recurrent infections, particularly viral infection with other disorders in childhood are us...

background bone marrow transplantation (bmt)is nowadays used in various hematological disorders including leukemias. hemophilia a & b are sex linked bleeding disorders in which there are various genetic abnormalities in factor viii & ix genes. among various hematological disorders, bleeding disorders mainly hemophilia in now widely treated using plasma derived and recombinant factor viii & ix c...

Blood coagulation is a critical hemostatic process that must be properly regulated to maintain a delicate balance between bleeding and clotting. Disorders of blood coagulation can expose patients to the risk of either bleeding disorders or thrombotic diseases. Coagulation diagnostics using whole blood is very promising for assessing the complexity of the coagulation system and for global measur...

A case is described of disseminated intravascular coagulation in a premature female infant, with the unusual and predominating feature of myocardial infarction consequent upon coronary vein thrombosis.Some reference is made to the incidence of coagulation disorders in the newborn and to methods of histological diagnosis.

Disseminated intravascular coagulation is a pathologic syndrome with different medical disorders. Diagnosis and treatment of this syndrome is one of the difficult managements in medical science. Thromboelastogram is the only guide for early diagnosis and precise management of this syndrome. We describe a patient who developed disseminated intravascular coagulation due to endocarditis and spleen...

The coagulation and immune systems, two vital systems in the human body, share intimate connections that fundamentally determine patient health. These work together through several common regulatory pathways, including Tissue Factor (TF) Pathway. Immune cells expressing TF producing pro-inflammatory cytokines can influence coagulation, while factors processes reciprocally impact responses by ac...

The first model of coagulation was proposed in the 1960s. Although the cascade concept of coagulation represented a significant advance in understanding of coagulation system and served for many years as a useful model, more recent clinical and experimental observations demonstrate that the cascade/waterfall hypothesis does not fully and completely reflect the events of haemostasis in vivo. The...