نتایج جستجو برای: cobalamin metabolism

تعداد نتایج: 226554  

Journal: :Thrombosis and haemostasis 1998
M Cattaneo M Vecchi M L Zighetti S Saibeni I Martinelli P Omodei P M Mannucci R de Franchis

BACKGROUND AND AIMS Why patients with inflammatory bowel disease are at increased risk for thrombosis is unknown. Since they may have impaired absorption of vitamins that regulate the metabolism of homocysteine, we tested the hypothesis that they have hyperhomocysteinemia, an established risk factor for arterial and venous thrombosis. METHODS The concentrations of total homocysteine (tHcy), f...

2016
Insa Buers Petra Pennekamp Yvonne Nitschke Chrishanthi Lowe Boris V. Skryabin Frank Rutsch

The rare inborn cblF defect of cobalamin metabolism is caused by mutations in the limb region 1 (LMBR1) domain containing 1 gene (LMBRD1). This defect is characterized by massive accumulation of free cobalamin in lysosomes and loss of mitochondrial succinyl-CoA synthesis and cytosolic methionine synthesis. Affected children suffer from heart defects, developmental delay and megaloblastic anemia...

2009
Per Byström Karin Björkegren Anders Larsson Linda Johansson Åke Berglund

BACKGROUND There are conflicting results on the role of cobalamin and folate for epidemiology and carcinogenesis in colorectal cancer patients and the need of supplementation for prevention of chemotherapy toxicity. PATIENTS AND METHODS Serum cobalamin, folate, and homocysteine were analysed before and during the treatment of 93 patients with advanced colorectal cancer (ACRC) with first-line ...

Journal: :The Netherlands journal of medicine 2003
L Th Vlasveld

BACKGROUND In patients with multiple myeloma a variety of metabolic events may occur. One of these are changes in the serum cobalamin (vitamin B12) concentration. Elevated as well as decreased serum cobalamin levels have been reported. The prevalence and clinical consequences of low cobalamin levels are largely unknown. OBJECTIVE To investigate the prevalence of low serum cobalamin levels in ...

2008
L. KISLIUK R. L. KIsLIUK

Two pathways for methionine methyl formation, one cobalamindependent and one cobalamin-independent, corresponding to those observed in Escherichia coli PA 15 have been found in Aerobacter aerogenes. An initial difficulty in showing the cobalamin-dependent pathway in cellfree extracts proved to be due to the presence of enzymes which caused the removal of adenosylmethionine, a cofactor required ...

Journal: :Journal of bacteriology 1999
N Shearer A P Hinsley R J Van Spanning S Spiro

A pleiotropic mutant of Paracoccus denitrificans, which has a severe defect that affects its anaerobic growth when either nitrate, nitrite, or nitrous oxide is used as the terminal electron acceptor and which is also unable to use ethanolamine as a carbon and energy source for aerobic growth, was isolated. This phenotype of the mutant is expressed only during growth on minimal media and can be ...

Journal: :Clinical chemistry 2003
Anne-Lise Bjørke Monsen Helga Refsum Trond Markestad Per Magne Ueland

BACKGROUND Recent data indicate that cobalamin and folate status, including the metabolic markers methylmalonic acid (MMA) and total homocysteine (tHcy), undergo marked changes during childhood, particularly during the first year. METHODS Serum cobalamin, serum and whole-blood folate, and plasma MMA and tHcy were determined in a cross-sectional study of 700 children, ages 4 days to 19 years. ...

Journal: :Clinical chemistry 2003
Ralph Carmel

BACKGROUND Low cobalamin concentrations are common, but their causes are often unknown. Transcobalamin I/haptocorrin (TC I/HC) deficiency, viewed as a rare cause, has not been examined systematically in patients with unexplained low serum cobalamin. METHODS Total TC I/HC was measured by RIA in three subgroups of 367, 160, and 38 patients with different categories of low cobalamin concentratio...

Journal: :The Annals of pharmacotherapy 2002
Lenee A Lane Carlos Rojas-Fernandez

OBJECTIVE To evaluate the use of oral cyanocobalamin therapy in the treatment of cobalamin (vitamin B(12))-deficient anemia. DATA SOURCES Primary and review articles were identified by MEDLINE search (1966-May 2000) and through secondary sources. DATA SYNTHESIS Cobalamin-deficient anemia is among the most common diagnoses in older populations. Cobalamin-deficient anemia may be diagnosed as ...

Journal: :The Biochemical journal 1996
A Yerima A Safi I Gastin J C Michalski M Saunier J L Gueant

We have purified a cobalamin-binding protein obtained by papain digestion of pig intestine by cobalamin-AH-Sepharose affinity chromatography, with a purification factor of 17,300, a yield of 63% and a cobalamin-binding activity of 11,260 pmol/mg of protein. The protein contained 3.8% carbohydrate and was O- and N-glycosylated. Its molecular mass was 69 kDa on SDS/PAGE and its isoelectric point ...

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