BACKGROUND The purpose of this study was to assess the in vivo ability of glucosaminic acid-cobalt (II) chelate to reduce glycemia. METHODS Different concentrations of chelate solution were administrated to mice with diabetes induced by streptozotocin. RESULTS Daily oral administration of chelate solution 0.4 mL at various concentrations (0.32-0.4 g/mL) led to reduction in water intake by t...

A series of highly unsymmetric heterobinuclear Mn/Co complexes is reported, in which an organometallic CpMn(CO)z fragment and a classical Werner-type cobalt(II) subunit are arranged in close proximity by means of a bridging pyrazolate. Two ligand scaffolds are employed that differ by the chelate size of the tripodal tetradentate {N41 binding site for cobalt. Molecular structures of three comple...

A recent technique involving the use of paper electrophoresis is described for the study of equilibria in binary complex systems in solution. The stability constants of the ML and ML2 complex species of some metal ions, namely beryllium(II) and cobalt(II), with hydroxyproline were determined in 0.1 mol L perchloric acid and a temperature of 35 °C. The logarithm stability constants of the ML and...

The anaerobic biosynthesis of vitamin B12 is slowly being unravelled. Recent work has shown that the first committed step along the anaerobic route involves the sirohydrochlorin (chelation of cobalt into factor II). The following enzyme in the pathway, CbiL, methylates cobalt-factor II to give cobalt-factor III. Recent progress on the molecular characterization of this enzyme has given a greate...

The cysG gene of Salmonella typhimurium is involved in synthesis of both cobalamin (B12) and siroheme (a cofactor required for SO3(2-) and NO2(2-) reductases). The failure to reduce SO3(2-) leads to cysteine auxotrophy, for which the enzyme is named. Although Escherichia coli does not synthesize B12 de novo, it possesses a very similar CysG enzyme which has been shown to catalyze two methylatio...

In this paper, the effect of nanocatalytic metal-organic framework based on copper metal and bis-tetrazolamine (CuBTA) ligand functionalized with cobalt (II) oxide nanoparticles on the thermal decomposition behavior of ammonium perchlorate (AP), using differential survey calorimetry (DSC) has been reviewed. First, the metal-organic framework (CuBTA) was synthesized from the raw materials of cop...

the present work describes a selective, rapid and sensitive method for the determination of cobalt using the adsorptive differential pulse voltammetry technique. the method is based on the accumulation of co(ii) complex with 2-aminocyclopentene-1-dithiocarboxylic acid on a hanging mercury drop electrode, followed by measurement of the current of the adsorbed complex. the effects of experimental...