Codeine has been prescribed to pediatric patients for many decades as both an analgesic and an antitussive agent. Codeine is a prodrug with little inherent pharmacologic activity and must be metabolized in the liver into morphine, which is responsible for codeine's analgesic effects. However, there is substantial genetic variability in the activity of the responsible hepatic enzyme, CYP2D6, and...

Curiosity about codeine can lead to copious information, so first it?s good to focus on the basics. Codeine is a prescription opioid/narcotic analgesic [2] that?s typically used to reduce coughing or to relieve mild to moderate pain by acting on the central nervous system (CNS, more on this later). That said, it?s good to be aware of potential risks associated with taking this medication. Codei...

Curiosity about codeine can lead to copious information, so first it?s good to focus on the basics. Codeine is a prescription opioid/narcotic analgesic [2] that?s typically used to reduce coughing or to relieve mild to moderate pain by acting on the central nervous system (CNS, more on this later). That said, it?s good to be aware of potential risks associated with taking this medication. Codei...

To determine whether the antidiarrheal action of opiate drugs in humans is due to enhanced intestinal absorption rates, as suggested by recent experiments in animals, or is due to altered intestinal motility, as traditionally thought, we studied the effect of therapeutic doses of codeine on experimental diarrhea and on the rate of intestinal absorption of water and electrolytes in normal human ...

Curiosity about codeine can lead to copious information, so first it?s good to focus on the basics. Codeine is a prescription opioid/narcotic analgesic [2] that?s typically used to reduce coughing or to relieve mild to moderate pain by acting on the central nervous system (CNS, more on this later). That said, it?s good to be aware of potential risks associated with taking this medication. Codei...

We report the production and comparative specificities of antisera raised to different immunogens containing codeine, morphine, and oxycodone. Antisera raised to bovine serum albumin (BSA) conjugates of codeine-6-hemisuccinate, ethylmorphine-6-hemisuccinate, or oxycodone-6-carboxymethyloxime had greatest recognition of structural changes around the piperidine ring nitrogen atom and th 14-positi...

OBJECTIVE To compare the performance of ibuprofen vs codeine for postoperative pain management after tonsillectomy as measured by need for emergency department (ED) treatment for pain and/or dehydration. STUDY DESIGN Retrospective case series with chart review. SETTING Tertiary children's hospital. SUBJECTS AND METHODS Consecutive series of patients who underwent tonsillectomy with or wit...

Postmortem samples from 14 cases of suspected heroin overdose were subjected to a preliminary systematic toxicological analysis in order to highlight the presence of unknown exogenous compounds (e.g., drugs of abuse, alcohol) that may have played a role in the mechanism of death. This analysis unveiled histories of poly-drug use in seven of the cases under investigation. Moreover, the concentra...

Curiosity about codeine can lead to copious information, so first it?s good to focus on the basics. Codeine is a prescription opioid/narcotic analgesic [2] that?s typically used to reduce coughing or to relieve mild to moderate pain by acting on the central nervous system (CNS, more on this later). That said, it?s good to be aware of potential risks associated with taking this medication. Codei...

The present study aimed to investigate the stability of morphine, morphine-3-β-glucuronide (M3G), morphine-6-β-glucuronide (M6G), 6-acetylmorphine (6-AM) from heroin metabolites, and codeine, codeine-6-glucuronide, nor-codeine, fentanyl, norfentanyl, paracetamol, caffeine its adulterants at room temperature for 24 hours in order understand effect instability postmortem redistribution (PMR). m...