For a finite field $mathbb{F}_q$, the bivariate skew polynomial ring $mathbb{F}_q[x,y;rho,theta]$ has been used to study codes cite{XH}. In this paper, we give some characterizations of the ring $R[x,y;rho,theta]$, where $R$ is a commutative ring. We investigate 2-D skew $(lambda_1,lambda_2)$-constacyclic codes in the ring $R[x,y;rho,theta]/langle x^l-lambda_1,y^s-lambda_2rangle_{mathit{l}}.$ A...