Recovery from destruction by sodium deoxycholate (DOC) was studied with the receptor membrane of the blowfly, Phormia regina. The recovery can be divided into two processes, colchicine dependent and colchicine independent. The colchicine-dependent process was completely depressed by pretreatment with colchicine at 5 mM for 2 min (partially at 0.1 mM for 10 min), but the colchicine-independent o...

The effects of colchicine and heavy water on cell division in wheat roots have been examined by means of mitotic index measurements correlated with an electron-microscope examination of the tissue. Heavy water alone caused an arrest of mitosis both in normal tissue and in roots which had been brought into partial synchrony of division by means of 5-aminouracil. Colchicine alone caused an accumu...

OBJECTIVE This study assessed the efficacy and safety of canakinumab, a fully human anti-interleukin 1β monoclonal antibody, for prophylaxis against acute gouty arthritis flares in patients initiating urate-lowering treatment. METHODS In this double-blind, double-dummy, dose-ranging study, 432 patients with gouty arthritis initiating allopurinol treatment were randomised 1:1:1:1:1:1:2 to rece...

Previous studies have shown that anti microtubule agents disrupt Golgi complexes in hepatocytes and other cells, causing breakdown or vesiculation of Golgi cisternal membranes. Whether this change in the structure of the Golgi membranes is associated with changes in Golgi membrane function is not known. The present study was initiated to investigate this issue; i.e., to determine whether anti-m...

This is a case report of 8-year-old child with lichen planus pigmentosus (LPP), rare subtype pediatric planus, successfully treated colchicine after failure other therapeutic options. Colchicine was introduced at dose 0.5mg/day for 1 year sun protection, resulting in cessation the eruption's extension and decrease hyperpigmentation. No adverse effects were observed. highlights potential as trea...

Sir, We read with great interest the recent letter by Sadjadi & Moshir (1) concerning the treatment of acne vulgaris with colchicine. The authors reported an improvement in all 22 selected patients after 2 months of administration of a daily dose of 1 mg of colchicine. The effectiveness of the drug was more evident in the patients with severe acne vulgaris. They recommended this drug as a possi...

OBJECTIVE To review the evidence for the efficacy and safety of colchicine in children with pericarditis. DESIGN Systematic review. SEARCH STRATEGY The following databases were searched for studies about colchicine in children with pericarditis (June 2015): Cochrane Central, Medline, EMBASE and LILACS. ELIGIBILITY CRITERIA All observational and experimental studies on humans with any leng...

Background Despite the great results of SARS-CoV-2 vaccine, there is an increasing need for effective therapeutics. Increasing viral loads are associated with systemic inflammatory response, more disease progression, and increased mortality, while exaggerated immune responses result in overreaction cytokine storm (CS)-induced acute lung injury. We hypothesize that ivermectin by reducing load co...

Gloriosa superba is a very important medicinal plant that is used for the treatment of diseases like Gout, arthritis, cancer and act as anthelmintic, antimitotic and antiabortive agent. Its tuber is a great source of Colchicine for the pharmaceutical industries and requires drying before extraction. The accelerated artificial drying technique using Microwave Vacuum oven was evaluated with other...

Background: Colchicine intoxication is uncommon but potentially life threatening because of the high toxicity of the drug. Colchicine binds to the intracellular protein tubulin, causing disturbed mitosis in all tissues followed by multi-organ failure. Case Presentation: We report a case of a 23-year-old woman admitted to emergency room 12 hours after a suicide attempt by ingestion of approximat...