The increased incidence of Crohn's disease in smokers has been recently reported, suggesting a strong association of cigarette smoke (CS) with colitis. However, the mechanism of the action of CS on colitis has not yet been explored. Here, we demonstrate that CS exposure is sufficient to induce colitis in mice. Interestingly, the colitis is mainly mediated by Th1, but not Th17, responses. CD4+ T...

Ustekinumab for Refractory Colitis Two patients in whom severe refractory autoimmune colitis developed after cancer treatment with immune checkpoint inhibitors had a response to course of subcuta...

abstract cytomegalovirus (cmv) is a virus that can be consider as invasive infection after transplantation or chemotherapy, long-term corticosteroid users or in immunodeficient patients such as hiv. different complications were seen in immunocompetent patients but colitis rarely occurs. the diagnosis of cmv was based on pathology by colonoscopy, positive cmv antigen and high cmv-igm titer serum...

ulcerative colitis is a chronic disease that specifically affects the mucosa of the rectum and colon. although the etiology of this recurring inflammatory disorder remains essentially unknown, there have been significant advances in identifying the likely genetic and environmental factors that contribute to its pathogenesis. the clinical course of the disease typically manifests with remissions...

ulcerative colitis (uc) is a nonspecific acute and chronic inflammatory bowel disease that diffusely involves the colonic mucosa. the etiology of uc has not yet been elucidated fully. however, many studies have found that immunologic disorders may play a role in the pathogenesis of uc. in addition, due to an increased frequency of uc in families, especially an increased monozygotic compared wit...

The aim of this study was to investigate the effects of citicoline on the development of colitis and antioxidant parameters in rats subjected to tribenzene sulfonic acid (TNBS)-induced colitis. Twenty four Wistar Albino female rats were divided into four subgroups (n=6) (control, colitis control, colitis + 50 mg/kg citicoline, colitis + 250 mg/kg citicoline). Colitis was induced using an enema ...

Gαi2-deficient mice spontaneously develop colitis. Using xMAP technology and RT-PCR, we investigated cytokine/chemokine profiles during histologically defined phases of disease: (i) no/mild, (ii) moderate, (iii) severe colitis without dysplasia/cancer and (iv) severe colitis with dysplasia/cancer, compared with age-matched wild-type (WT) littermates. Colonic dysplasia was observed in 4/11 mice ...

Both chronic ulcerative colitis and smoking are associated with colorectal cancer in humans. In the present study, we investigated the effects of cigarette smoke (CS) exposure on inflammation-associated tumorigenesis in the mouse colon. Male balb/c mice were allocated into six groups: control, CS (2%), CS (4%), colitis, colitis + CS (2%) and colitis + CS (4%). They were given water or 3% dextra...

We have developed a high-resolution in vivo MRI method to assess the state of colitis and to facilitate the early detection of colitis-associated colorectal tumors in mice. From high-resolution T1/T2-weighted MR images, dynamic contrastenhanced MRI (DCEMRI) studies with Gd-DTPA, and in vitro immuno-histological studies of control, colitis, tumor, and colitis-to-early colorectal tumor-bearing mi...

Neutrophils have been implicated as major contributors to tissue injury in inflammatory bowel disease. In this study, we have assessed the effects of an inhibitor of neutrophil activation and adherence, NPC-18915 (4-{2-[2-(2-benzofuranyl)phenyl]-(E)-ethenyl}benzoic acid sodium salt), in models of both acute and reactivated colitis. Acute colitis was induced by intracolonic administration of a h...