The focal adhesion kinase (FAK) is a protein tyrosine kinase linked to signaling events between cells and the extracellular matrix. Studies at the Western blot level have demonstrated up-regulation of FAK expression in invasive breast and colon cancers. To assess p125FAK expression at the cellular level, we developed monoclonal antibodies that specifically detected FAK in formalin-fixed, paraff...

The headlines stemming from colon cancer treatment and prevention are abundant these days. From one source (medicalnewstoday.com) in the past month alone, there are news stories with headlines like, “... Scientists patent an effective drug for treating breast, colon, and skin cancers,” and “Newly identified biomarker may help predict colon cancer progression, personalize therapy.” So how do you...

background: breast cancer incidence has increased rapidly inkuwait, but there haven’t been any studies investigating the recognized risk factors of breast cancer inkuwait. the aim of the study was to investigate breast cancer risk factors among women inkuwait.   methods: a case-control study was conducted in kuwait from may 2003 to march 2004 using a questionnaire including socio-demographic da...

BACKGROUND The National Cancer Institute Community Cancer Centers Program (NCCCP) pilot was designed to improve quality of cancer care and reduce disparities at community hospitals. The NCCCP's primary intervention was the implementation of the Commission on Cancer Rapid Quality Reporting System (RQRS). The RQRS is a hospital-based data collection and evaluation system allowing near real-time a...

PURPOSE Health care priorities of individuals may change during a pandemic, which may, in turn, affect health services utilization. We examined Canadians' online relative search interest five common solid tumors (breast, colon, lung, prostate, and thyroid) the COVID-19 pandemic to that observed same months prior 5 years. METHODS conducted cross-sectional retrospective study using Google Trends ...

Trifluoroacetic acid-promoted Wagner-Meerwein rearrangement of betulonic acid carboxamide led to the formation expected 19β,28-lactam along with a new germanicane-type 3-oxo-19β-trifluoroacetoxy-18αH-oleane-28-oic acid. The structure this triterpenoid was confirmed by 2D NMR analyses. A primary evaluation biological potency revealed an anticancer activity GI50 < 5 μM against leukemia, colon ...

Background and objective: Helicobacter pylori infection is one of the most common chronic bacterial infections in the world, especially in the developing countries. This bacterium is the cause of many diseases such as lymphoma, gastritis, peptic ulcers, and stomach cancer. According to recent reports, H. pylori infection can potentially increase the risk of colon cancer. The cu...

colorectal cancer (crc) metastasis to the thyroid gland is rare. here wereport a 45 yr-old man in western iran referred to hematology clinic, kermanshah city, iran in march 2014 with complaint of exertional dyspnea, multi-nodular goiter as well as complaint of exertional dyspnea, and multi-nodular goiter. his history included a low anterior resection of rectum in 9 months ago for a high-risk st...

PURPOSE The application of Cox proportional hazards (CoxPH) models to survival data and the derivation hazard ratio (HR) are well established. Although nonlinear, tree-based machine learning (ML) have been developed applied analysis, no methodology exists for computing HRs associated with explanatory variables from such models. We describe a novel way compute ML using SHapley Additive exPlanati...

CONTEXT There is conflicting evidence on whether people with schizophrenia have a different risk of cancer from that of the general population. OBJECTIVE To determine the risk of 6 common cancers in patients with schizophrenia or bipolar disorder. DESIGN Population-based, nested, case-control study. SETTING A total of 454 practices contributing to the QRESEARCH general practice database. ...