Background and aims: The purpose of this study was to evaluate the utility of easily measured clinical variables at flexible sigmoidoscopy (FS) screening that might predict a proximal advanced neoplasm (PAN). Methods: We studied 1833 subjects with biopsy verified adenomas at FS who subsequently underwent full colonoscopy. Results: A total of 387 (21%) subjects had proximal colonic neoplasms (PC...

BACKGROUND Computed tomographic colonography (CTC) is a new technique for detecting colonic neoplasms. Data on the utility of this method in the Indian population are limited. METHODS Forty-two patients with symptoms of colonic disease underwent CTC and conventional colonoscopy (CC) within one week of each other and the findings at these two investigations were compared. RESULTS The entire ...

Chronic inflammation raises the risk of the development of colorectal cancer (CRC). Green tea catechins (GTCs), which possess anti-inflammatory properties, are known to be anti-carcinogenic in a variety of organ sites, including the colorectum. This study investigated whether (-)-epigallocatechin gallate (EGCG), a candidate chemopreventive agent and major biologically-active component of green ...

Introduction: Aggressive fibromatosis (desmoid tumor) is a locally invasive soft tissue lesion, composed of a monoclonal proliferation of benignappearing spindle (fibroblast like) cells. A subset of lesions contain a somatic mutation in the adenomatous polyposis coli (APC) gene (1). Familial Adenomatosis Polyposis (FAP) is an inherited pre-neoplastic condition that predisposes to colonic neopla...

Normal colonic epithelial cells undergo maturation as they traverse the crypt to the lumenal surface. The binding of lectins to goblet cell mucins and other glycoconjugates changes as the cells migrate and differentiate. Additional stepwise modifications in glycoconjugate expression occur in premalignant and malignant neoplasms that may be detected by lectin binding studies. The lectins Dolicho...

BACKGROUND Mucinous cystic neoplasms arise in the ovary and various extra-ovarian sites. While their pathogenesis remains conjectural, their similarities suggest a common pathway of development. There have been rare reports involving the mesentery as a primary tumour site. CASE PRESENTATION A cystic mass of uncertain origin was demonstrated radiologically in a 22 year old female with chronic ...

AIMS To report five malignant trichogenic tumours arising in longstanding, previously benign adnexal neoplasms through malignant transformation. Malignant trichogenic adnexal tumours are extremely rare neoplasms. METHODS AND RESULTS The patients were between 55 years and 79 years of age. Three of the tumours were located on the arms, two on the face. Three of our patients had a history of chr...

BACKGROUND AND AIMS Diminished folate status is associated with enhanced colorectal carcinogenesis. This study investigated the potential chemopreventive role of dietary folate in the dimethylhydrazine colorectal cancer model. SUBJECTS AND METHODS Sprague-Dawley rats were fed diets containing either 0, 2 (daily dietary requirement), 8 or 40 mg folate/kg diet for 20 weeks. After five weeks of ...

spindle cell neoplasms are defined as neoplasms that consist of spindle-shaped cells in the histopathology. spindle cell neoplasms can affect the oral cavity. in the oral cavity, the origin of the spindle cell neoplasms may be traced to epithelial, mesenchymal and odontogenic components. this article aims to review the spindle cell neoplasms of the oral cavity with emphasis on histopathology.  ...

In this article I review the association between exposure to carrageenan and the occurrence of colonic ulcerations and gastrointestinal neoplasms in animal models. Although the International Agency for Research on Cancer in 1982 identified sufficient evidence for the carcinogenicity of degraded carrageenan in animals to regard it as posing a carcinogenic risk to humans, carrageenan is still use...