objectives: to investigate fasting glucose, glucose tolerance, insulin resistance and insulin–like growth factor 1 in patients with or without colorectal polyps. materials and methods: in this cross-sectional study, we evaluated fasting glucose, insulin, insulin–like growth factor 1 (igf-1), lipid profile and glucose tolerance test in 103 patients undergoing colonoscopy (52 normal and 53 with a...

toll-like receptor 4 (tlr4), considered one of  the most important tlr, recognizes lipopolysaccharide of  gram-negative bacteria. recognition  of  ligands by  tlrs  induces signaling pathways resulting in activation of transcriptional factors such as nf-κb which are involved in  the  expression of  inflammatory cytokines and  chemokines. to  prevent  an inappropriate immune response, a complex ...

the innate immune system recognizes the presence of bacterial products through the expression of a family of membrane receptors known as toll-like receptors (tlrs). polymorphisms in tlrs have been shown to be associated with increased susceptibility to diseases such as inflammatory bowel disease. the aim of this study was to determine whether there was a correlation between polymorphisms of tlr...

background: cancer is the third most common cause of death in iran. colorectal cancer is an ideal tumor for screening. therefore, early diagnosis through screening can reduce its prevalence and mortality. on the other hand, knowledge of practitioners about screening programs has a direct relationship with their performance. methods: in the present cross-sectional-educational study, knowledge, a...

background: colorectal cancer (crc) is the second cause of cancer-related deaths worldwide. there have been several studies reporting the proximal tumor shift, especially in western countries. in the present study, we investigated the clinicopathologic and anatomical distributions of colorectal tumors in iranian crc patients. materials and methods: in this retrospective cohort study,258 patient...

familial adenomatous polyposis (fap) is responsible for < 1% of colorectal cancer (crc) cases and is inherited as an autosomal dominant trait. patients generally present hundreds to thousands of adenomas and develop colorectal cancer by age 35- 40 if left untreated. here we report four patients with germline frameshift mutation (small deletion) at exon 15 of adenomatous polyposis coli (apc) tum...

objective: e-cadherin is widely down-regulated and tightly associated with tumor invasion and metastasis in multiple human cancer types. recent studies have shown that aberrant methylation of the e-cadherin gene promoter contributes to its silencing. however, information regarding epigenetic inactivation of e-cadherin in colorectal cancer is insufficient. herein, we correlate association of the...

background: the aim of this study was to assess epidemiology of colorectal cancer (crc) in isfahan, iran. materials and methods: data were gathered from hospital documents of hospital admissions for colonoscopy, surgery, chemotherapy or radiotherapy due to colorectal cancer during 1996-2003. results: 1100 cases with colorectal cancer in seven years were detected and reviewed. our minimum incide...

introduction: colorectal cancer is the most common cancer of the alimentary system. in women, it is the second leading cause of mortality after breast cancer while in men, it is the third leading cause of death after lung and prostate carcinoma. prevalence is more in population older than 50 years and increases in older people. therefore, best treatment and prognosis is early diagnosis of disea...

aim : the aim of this study was to compare prognostic factors between colon and rectal cancers. background : prognosis of colorectal cancer (crc) may depend on the anatomical site. patients and methods : a total of 1219 patients with crc diagnosis according to the pathology report of rcgld cancer registry, from 1 january 2002 to 1 october 2007, were entered into the study. demographic and clini...