While venous thromboembolism (VTE) is rare in young women of reproductive age, combined oral contraceptives increase the risk of VTE. In the patient in whom combined hormonal contraception is appropriate, it is reasonable to use any currently available preparation.

OBJECTIVE To investigate the association between use of combined oral contraceptives and risk of venous thromboembolism, taking the type of progestogen into account. DESIGN Two nested case-control studies. SETTING General practices in the United Kingdom contributing to the Clinical Practice Research Datalink (CPRD; 618 practices) and QResearch primary care database (722 practices). PARTIC...

The effect upon tryptophan metabolism of the use of combined oestrogen-progestagen oral contraceptives containing a low (0.05 mg) dose of oestrogen, or of the continuous administration of megestrol acetate, has been studied by determining the excretion of tryptophan metabolites in urine collected after a 2 g oral dose of the amino acid. An investigation of 10 women before being given oral contr...

conclusions the results of the present study demonstrate that oral contraceptives containing estradiol can lead to candida colonization in the oral cavity. it is recommended that further studies comparing the influence of oral contraceptives on candida’s adherence to the epithelium is highly recommended. results the frequency of positive cultures of candida albicans was higher (p value = 0.03) ...

In this week’s issue of The BMJ, Vinogradova and colleagues (doi:10.1136/bmj.h2135) report the results of a large study on the effects of combined oral contraceptives on the risk of venous thromboembolism, conducted in two large United Kingdom databases: the Clinical Practice Research Datalink (CPRD) and QResearch. The authors identified over 10 500 cases of VTE in women aged 15-49 years and ar...