Polymeric surfaces in contact with blood in vivo are foreign bodies and are quickly isolated from blood by the non-specific defense systems. Nanoparticles (NP) used as drug carriers are normally quickly taken up by phagocytes and sequestered in liver and spleen to which they can deliver drugs. Long-circulating and/or low complement activating core-shell NPs can be obtained from PEO/PEG amphiphi...

Inflammation is associated with development of atherosclerosis, and cholesterol crystals (CC) have long been recognized as a hallmark of atherosclerotic lesions. CC appear early in the atheroma development and trigger inflammation by NLRP3 inflammasome activation. In this study we hypothesized whether CC employ the complement system to activate inflammasome/caspase-1, leading to release of matu...

Peripheral blood eosinophils from patients with eosinophilia and from healthy subjects were studied for surface immunoglobulins, receptors for the Fc region of IgG, complement receptors, and spontaneous rosette formation with sheep and mouse erythrocytes. Eosinophils were found to have receptors for complement and for aggregated IgG, and to have the same two types of complement receptors as do ...

i. Radiological examination of chest, teeth, sinuses, and lumbo-sacral joints. 2. Blood tests including a full blood count, erythrocyte sedimentation rate (ESR), antistreptolysin titre, mucoprotein levels, blood sugar levels, gonococcal complement-fixation test, toxoplasma dye and complement-fixation tests, Rose latex test for arthritis, serum protein electrophoresis, histoplasma complement-fix...

abstract introduction: thalassemia is the most common hereditary anemia in iran. the aim of this study was to evaluate the humoral immune system and assess the effect of splenectomy on the serum level of immunoglobulins igg, igm, and iga and complement components in patients with major thalassemia. materials and methods: this interventional semi-experimental study (before-after) was performed o...

i. Radiological examination of chest, teeth, sinuses, and lumbo-sacral joints. 2. Blood tests including a full blood count, erythrocyte sedimentation rate (ESR), antistreptolysin titre, mucoprotein levels, blood sugar levels, gonococcal complement-fixation test, toxoplasma dye and complement-fixation tests, Rose latex test for arthritis, serum protein electrophoresis, histoplasma complement-fix...

In the present study, we have shown the vast importance of biomaterial nanotexture when evaluating inflammatory response. For the first time in an in vitro whole blood system, we have proven that a small increase in nanoporesize, specifically 180 nm (from 20 to 200 nm), has a huge effect on the complement system. The study was done using nanoporous aluminiumoxide, a material that previously has...

T HE RECOVERY of some patients after transfusion of large volumes of incompatible erythrocytes suggests that the effects of such unfortunate accidents do not depend solely on the volume of blood given.1 ‘ 2 , 3 In experimental transfusion reactions produced by the injection of incompatible whole blood into isoimmunized dogs4 ‘ it was noted that the degree of hemoglobinemia induced was not direc...

ABO histo-blood group antigens have been postulated to modify pathogen spread through the action of natural antibodies and complement. The antigens are generated by a polymorphic glycosyl-transferase encoded by 2 dominant active and a recessive inactive allele. In this study we investigated whether ABO sugars are incorporated into the envelope of HIV-1 virions. HIV vectors derived from cells ex...

Effective gene therapy for diseases of the circulation requires vectors capable of systemic delivery. The molecular weight of poly(L-lysine) (pLL) has a significant effect on the circulation of pLL/DNA complexes in mice, with pLL(211)/DNA complexes displaying up to 20 times greater levels in the blood after 30 minutes compared with pLL(20)/DNA. It is shown that pLL(20)/DNA complexes fix mouse c...