The ability of pea protein isolates (PPI) to form complex coacervates with tragacanth gum was investigated. coacervate formation structurally compared three other PPI-polysaccharide interaction models: arabic and sodium alginate (known PPI) tara gum, a galactomannan. effects the pH protein/polysaccharide ratio were mainly investigated using turbidity zeta potential measurements. Regarding solub...

Fabrication of oil (hexylsalicylate) encapsulated microcapsules comprising a shell gum Arabic and fungal chitosan via complex coacervation was investigated herein. This study highlights the influence fabrication conditions including ratio to chitosan, their net electrokinetic charge/zeta-potential turbidity on physico-mechanical properties resulting microcapsules. Glutaraldehyde employed as che...

The tropoelastin monomer undergoes stages of association by coacervation, deposition onto microfibrils, and cross-linking to form elastic fibers. Tropoelastin consists of an elastic N-terminal coil region and a cell-interactive C-terminal foot region linked together by a highly exposed bridge region. The bridge region is conveniently positioned to modulate elastic fiber assembly through associa...

Following cellular secretion into the extracellular matrix, tropoelastin is transported, deposited, and cross-linked to make elastin. Assembly by coacervation was examined for an isoform of tropoelastin that lacks the hydrophilic domain encoded by exon 26A. It is equivalent to a naturally secreted form of tropoelastin and shows similar coacervation performance to its partner containing 26A, the...

Coacervation is usually defined as the spontaneous formation of a dense liquid phase from a macromolecular solution of poor solvent affinity. In "coacervation", the loss of solvation arises from the interaction of complementary macromolecular species. The formation of such macromolecule-rich fluids is well-known in mixtures of complementary polyelectrolytes; it can also occur from mixtures of p...

The discovery of membraneless organelles (MLOs) formed by liquid-liquid phase separation raised many questions about the spatial organization biomolecular processes in cells, but also offered a new tool to mimic cellular media. Since disordered and charged protein domains are often necessary for separation, coacervates can be used as models both understand MLO regulation develop dynamic cellula...

Microspheres (MS) of Ketorolac Tromethamine (KT) for oral delivery were prepared by complex coacervation (method-1) and simple coacervation (method-2) methods without the use of chemical crossâlinking agent (glutaraldehyde) to avoid the toxic reactions and other undesirable effects of the chemical cross-linking agents. Alternatively, ionotropic gelation was employed by using sodium-tripolyphosp...

It is a comparative study of salbutamol sulphate-ethylcellulose microcapsules prepared by three different microencapsulation techniques i.e. coacervation thermal change, solvent evaporation and coacervation non-solvent addition by adjusting the ratio of salbutamol sulphate to ethylcellulose. In vitro release profiles of microcapsules were studied using USP XXIV dissolution apparatus-I in 450 ml...