BACKGROUND AND OBJECTIVE Little is known about component-resolved diagnosis (CRD) for Dermatophagoides pteronyssinus (Der p) sensitization in the Chinese population. We aimed to evaluate sensitization to Der p components in southern China. METHODS Two-hundred immunotherapy-naïve patients with asthma and/or rhinitis positive to specific IgE (sIgE) against Der p extract, along with 20 Der p-neg...

Studies on Coding Region Determinant-Binding Protein (CRD-BP) and its orthologs have confirmed their functional role in mRNA stability and localization. CRD-BP is present in extremely low levels in normal adult tissues, but it is over-expressed in many types of aggressive human cancers and in neonatal tissues. Although the exact role of CRD-BP in tumour progression is unclear, cumulative eviden...

The tendency towards thin insulation layers in traction battery systems presents new challenges regarding quality and service life. Phase-resolved DC partial discharge diagnostics can help to identify defects. Furthermore, different root causes are characterized by patterns. However, industrialize the procedure, there is need for an automatic pattern recognition system. This paper shows how met...

of chronic renal disease (CRD). In contrast with patients who have acute renal disease, most patients with CRD progressively and irreversibly lose renal mass and the ability to carry out critical renal functions. If untreated, patients will have life-threatening complications develop. Treatment modalities such as dialysis and renal transplantation greatly reduce the risk of such complications, ...

Smoothened (Smo) is a member of the Frizzled (FzD) class of G-protein-coupled receptors (GPCRs), and functions as the key transducer in the Hedgehog (Hh) signalling pathway. Smo has an extracellular cysteine-rich domain (CRD), indispensable for its function and downstream Hh signalling. Despite its essential role, the functional contribution of the CRD to Smo signalling has not been clearly elu...

The brain stem is necessary for the expression of behavioral reactions to noxious visceral inputs. Neurons in raphe magnus (RM) and the adjacent nucleus reticularis magnocellularis (NRMC) respond to visceral stimuli and can facilitate the behavioral reaction to visceral stimulation. To determine which RM and NRMC cells could play a role in generating the reaction to colorectal distension (CRD),...

Methods We searched PubMed, Medline, Embase, Cinahl, the Cochrane Library, Univ of York CRD databases, EuroScan, LILACS, Indian Medlars, Index Medicus for SE Asia,health technology agencies and the Internet in all languages for articles from 01/01/1990 – 22/10/2010. Abstracts and full text articles were screened and included using pre-defined criteria. Disagreements were resolved by consensus a...

A 249-nucleotide coding region instability determinant (CRD) destabilizes c-myc mRNA. Previous experiments identified a CRD-binding protein (CRD-BP) that appears to protect the CRD from endonuclease cleavage. However, it was unclear why a CRD-BP is required to protect a well-translated mRNA whose coding region is covered with ribosomes. We hypothesized that translational pausing in the CRD gene...

Introduction: House dust mite (HDM) allergens are considered among the most essential elicitors of allergic rhinitis and asthma worldwide [1]. How can we determine individual sensitization profile a patient? Is there way to monitor development symptoms? it possible tailor different forms therapy based on patient?
 Purpose: The study aims show benefits molecular diagnostics allergies exampl...

We report here that neuregulin (NRG) isoforms with a conserved cysteine-rich domain (CRD) in their N terminus regulate expression of nicotinic acetylcholine receptors (nAChRs) at developing interneuronal synapses and report the isolation of transmembrane NRG isoforms with this CRD within the N-terminal portion. CRD-NRG mRNA and immunoreactive protein are detected early in developing presynaptic...