PURPOSE To investigate the clinical efficacy of low-dose chlormadinone acetate (CMA) in prostate cancer patients who suffer from hot flushes that is a major side effect of androgen deprivation therapy. METHODS Our study included 32 prostate cancer patients who had severe hot flush after undergoing hormone therapy for more than 3 months. The average age of the patients was 72.5 years. In the b...

In this paper, a new topology that is a symmetric five bar profile for displacement amplification is proposed, and a compliant mechanical amplifier (CMA) based on the new topology is designed to amplify the stroke of a piezoelectric actuator. The new CMA can convert the motion generated by a PZT actuator with a large amplification ratio (24.4) in a very compact size, and it has a high natural f...

Collismycin A (CMA), a microbial product, has anti-proliferative activity against cancer cells, but the mechanism of its action remains unknown. Here, we report the identification of the molecular target of CMA by ChemProteoBase, a proteome-based approach for drug target identification. ChemProteoBase profiling showed that CMA is closely clustered with di-2-pyridylketone 4,4-dimethyl-3-thiosemi...

This paper investigates adaptive blind equalization for multiple-input and multiple-output (MIMO) channels and its application to blind separation of multiple signals received by antenna arrays in communication systems. The performance analysis is presented for the CMA equalizer used in MIMO channels. Our analysis results indicate that double innnite-length MIMO-CMA equalizer can recover one of...

Equalization plays an important role for the communication system receiver to correctly recover the symbol send by the transmitter, where the received signals may contain additive noise and intersymbol interference (ISI). Blind equalization is a technique of many equalization techniques at which the transmitted symbols over a communication channel can be recovered without the aid of training se...

Oxidatively damaged proteins accumulate with age in almost all cell types and tissues. The activity of chaperonemediated autophagy (CMA), a selective pathway for the degradation of cytosolic proteins in lysosomes, decreases with age. We have analyzed the possible participation of CMA in the removal of oxidized proteins in rat liver and cultured mouse fibroblasts. Added to the fact that CMA subs...

This report proposes a simple modification of the Covariance Matrix Adaptation Evolution Strategy (CMA-ES) for high dimensional objective functions, that reduces the internal time and space complexity from quadratic to linear. The covariance matrix is constrained to be diagonal and the resulting algorithm, sep-CMA-ES, samples each coordinate independently. Because the model complexity is reduce...

Pseudomonas syringae pv. tomato DC3000 produces the phytotoxin coronatine, a major determinant of the leaf chlorosis associated with DC3000 pathogenesis. The DC3000 PSPTO4723 (cmaL) gene is located in a genomic region encoding type III effectors; however, it promotes chlorosis in the model plant Nicotiana benthamiana in a manner independent of type III secretion. Coronatine is produced by the l...

Wireless Sensor Networks (WSN) have been studied intensively for various applications such as monitoring and surveillance. Sensor deployment is an essential part of WSN, because it affects both the cost and capability of the sensor network. However, most deployment schemes proposed so far have been based on over-simplified assumptions, where results may be far from optimal in practice. Our prop...

Adaptive blind equalization has gained widespread use in communication systems that operate without training signals. In particular, the Constant Modulus Algorithm (CMA) has become a favorite of practitioners due to its LMS-like complexity and desirable robustness properties. The desire for further reduction in computational complexity has motivated signed-error versions of CMA, which have been...